Primjena ciklodekstrina u formulacijama nesteroidnih protuupalnih lijekova

master's thesis

• Title (english): The usage of cyclodextrins in formulations of non-steroidal anti-inflammatory drugs
• Author: Daniela Rogulj
• Mentor: Mario Jug (mentor)
• Committee member: Mario Jug (predsjednik povjerenstva)
• Committee member: Anita Hafner (član povjerenstva)
• Committee member: Dubravka Vitali Čepo (član povjerenstva)
• Granter: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of pharmaceutical technology); Zagreb
• Defense date and country: 2019-07-10, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract

Nesteroidni protuupalni lijekovi (NSAID) su skupina lijekova sa analgetskim, antipiretskim i protuupalnim djelovanjem koji se naširoko koriste u liječenju boli, vrućice i upalnih bolesti. Njihovi nedostaci su česta neučinkovitost i izazivanje brojnih nuspojava. Ciklodekstrini (CD) stvaranjem inkluzijskih kompleksa otvaraju mogućnost pripreme novih formulacija postojećih NSAID sa većom učinkovitošću i manjim rizikom pojave nuspojava. Uklapanjem NSAID u komplekse sa CD formulirani su pripravci prikladni za okularnu, parenteralnu i oralnu primjenu. Formulacije inkluzijskih kompleksa povećavaju topljivost pojedinih NSAID, a samim time i bioraspoloživot, brzinu nastupa i intenzitet djelovanja za sva tri puta primjene. Nadalje, CD reduciraju kontakt NSAID sa sluznicama što smanjuje lokalne iritacije i omogućava veću podnošljivost. CD mogu zamijeniti brojne štetne pomoćne tvari korištene u konvencionalnim formulacijama čime dodatno poboljšavaju sigurnosni profil NSAID. Na posljetku, CD predstavljaju veoma dobro podnošljive pomoćne tvari prihvatljive cijene koštanja sa potencijalom za dodatni razvoj formulacija NSAID poboljšanih karakteristika.

Abstract (english)

Non-steroidal anti-inflammatory drugs (NSAIDs) are a group of analgesic, antipyretic and anti-inflammatory drugs that are widely used in the treatment of pain, fever and inflammatory diseases. Their disadvantages are frequent inefficiency and numerous side effects. Cyclodextrins (CD) by creating inclusion complexes open the possibility of preparing new formulations of existing NSAIDs with higher efficacy and lower risk of side effects. By incorporating NSAIDs into complexes with CDs, formulations suitable for ocular, parenteral and oral administration are made. Formulations of inclusion complexes increase the solubility of particular NSAIDs and consequently the bioavailability, onset and intensity of drug effect for all three administration routes. Furthermore, CD reduces contact of NSAID with the mucous membrane, which reduces local irritation and allows greater drug tolerability. CD can replace many harmful adjuvants used in conventional formulations and increase additionally the NSAID safety profile. Ultimately, CDs are very well-tolerated adjuvants with acceptable price and potential for additional development of improved NSAID formulations.

• Keywords: NSAID; ciklodekstrini; inkluzijski kompleks
• Keywords (english): NSAIDs; cyclodextrins; inclusion complex
• Language: croatian
• URN:NBN: urn:nbn:hr:163:766049
• Study programme: Title: Pharmacy; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: magistar/magistra farmacije (magistar/magistra farmacije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2021-09-07 15:38:48