Farmakološka manipulacija endokanabinoidnim sustavom i rizik od razvoja metaboličkih bolesti

master's thesis

• Title (english): Pharmacological manipulation of the endocannabinoid system and the risk of development of metabolic diseases
• Author: Iris Flatscher
• Mentor: Lidija Bach-Rojecky (mentor)
• Committee member: Lidija Bach-Rojecky (predsjednik povjerenstva)
• Committee member: Maja Ortner Hadžiabdić (član povjerenstva)
• Committee member: Miranda Sertić (član povjerenstva)
• Granter: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of pharmacology); Zagreb
• Defense date and country: 2021-07-19, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract

Cilj ovog diplomskog rada je prikazati osnovne karakteristike endogenog kanabinoidnog sustava, s naglaskom na njegovu ulogu u regulaciji metaboličkih funkcija. U tom kontekstu naglasit će se učinci te rizici primjene kanabisa na razvoj pretilosti i šećerne bolesti. Iako postoje brojni rizični čimbenici razvoja šećerne bolesti, pretilost je jedan od bitnijih. Primjena kanabisa može uzrokovati razvoj pretilosti aktivacijom CB1 receptora u centrima za regulaciju gladi/sitosti. CB1 receptori prisutni su i na perifernim tkivima te zajedno s CB2 podtipom receptora sudjeluju u održavanju metaboličke homeostaze. Pritom su negativni učinci posljedica aktivacije CB1 receptora, dok agonističko djelovanje na CB2 receptore ima protektivo djelovanje. Pokazano je, također, da u pozadini brojnih komplikacija šećerne bolesti, poput dijabetičke neuropatije, nefropatije, retinopatije i kardiomiopatije dolazi do narušavanja modulatornog djelovanja endogenih kanabinoida. Stimulacija CB1 receptora egzogenim ligandima kao što je THC koji se unosi prilikom konzumacije marihuane, akutno i kronično povećava rizik metaboličkih promjena. Akutno, kanabis inducira razvoj intolerancije na glukozu, kao i unos hrane i pohranu energije. Njegova kronična primjena pak smanjuje unos hrane i porast tjelesne težine. Sve ovo govori u prilog kompleksnosti teme i potrebi za njezinim opširnijim objašnjenjem. Nova će znanja pridonijeti razumijevanju rizika akutne i kronične primjene kanabisa, a mogu usmjeriti i razvoj novih lijekova s djelovanjem na kanabinoidni sustav.

Abstract (english)

The aim of this thesis is to present the basic characteristics of the endogenous cannabinoid system, with emphasis on its role in the regulation of metabolic functions. In this context, the effects and risks of cannabis use on the development of obesity and diabetes will be emphasized. Although there are a number of risk factors for developing diabetes, obesity is one of the most important. Cannabis administration can cause the development of obesity by activating CB1 receptors in hunger / satiety control centers. CB1 receptors are also present on peripheral tissues and together with the CB2 receptor subtype participate in the maintenance of metabolic homeostasis. The negative effects are due to the activation of the CB1 receptor, while the agonist effect on the CB2 receptor has a protective effect. It has also been shown that in the background of numerous complications of diabetes, such as diabetic neuropathy, nephropathy, retinopathy and cardiomyopathy, the modulating action of endogenous cannabinoids is ordered. Stimulation of CB1 receptors by exogenous ligands such as THC, also increases the risk of metabolic changes when consuming marijuana, acutely and chronically. Acutely, cannabis induces the development of glucose intolerance, as well as food intake and energy storage. Its chronic use reduces food intake and increases body weight. All this speaks in favor of the complexity of the topic and the need for its extensive explanation. New knowledge will contribute to understanding the risks of acute and chronic cannabis use, and may direct and develop new drugs with effects on the cannabinoid system.

• Keywords: šećerna bolest; kanabis; pretilost; endokanabinoidni sustav
• Keywords (english): diabetes; cannabis; obesity; endocannabinoid system
• Language: croatian
• URN:NBN: urn:nbn:hr:163:696809
• Study programme: Title: Pharmacy; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: magistar/magistra farmacije (magistar/magistra farmacije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2022-02-02 12:37:32