Povezanost računskih hematoloških upalnih pokazatelja uoči primjene kemoterapije kod bolesnica s rakom dojke s ishodom bolesti

master's thesis

• Title (english): Relationship between computed haematological inflammatory parameters prior to chemotherapy in breast cancer patients with disease outcome
• Author: Martha Koržinek
• Mentor: Donatella Verbanac (mentor)
• Mentor: Ljiljana Mayer (mentor)
• Committee member: Donatella Verbanac (predsjednik povjerenstva)
• Committee member: Lidija Bach-Rojecky (član povjerenstva)
• Committee member: Ljiljana Mayer (član povjerenstva)
• Granter: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of medical biochemistry and haematology); Zagreb
• Defense date and country: 2021, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Medical Biochemistry

Abstract

Zbog visoke stope incidencije i mortaliteta karcinoma dojke važno je istraživati biljege koji mogu pomoći u ranoj dijagnostici i
praćenju karcinoma. Novi parametri za praćenje karcinoma dojke koji se istražuju su NLR, SII i PLR. NLR je omjer neutrofila i
limfocita. Može se računati kao omjer apsolutnog broja neutrofila i limfocita ili kao omjer postotka neutrofila i limfocita. PLR je
omjer broja trombocita i limfocita. Sustavno imunosno-upalni indeks (SII) određuje se na temelju NLR-a i broja trombocita.
Računa se kao umnožak NLR-a i broja trombocita. Cilj ovog rada bio je ispitati povezanost novih prediktivnih markera i
različitih karakteristika tumora kod pacijentica uoči kemoterapije. Kao metoda korišteno je retrospektivno prikupljanje podataka
dobivenih iz nalaza pacijenata. Razdoblje prikupljenih podataka je od 2015. do 2021. godine. Podaci koji su se prikupljali u
navedenom razdoblju su dob pacijenata, broj neutrofila, limfocita, trombocita i leukocita te molekularni podtip karcinoma dojke,
stadij tumora, status limfnih čvorova, histološki gradus, status vaskularne invazije, status estrogenskih i progesteronskih
receptora, HER-2 status i postotak Ki-67. Utvrđene granične vrijednosti za navedene parametre iznosile su : NLR 2,13, PLR
88,23 i SII 547.Statistički značajna P-vrijednost dobivena je za PLR i SII te stadij tumora, dok za druge parametre nije utvrđena
statistički značajna P-vrijednost. Za sva tri hematološka parametra učinjena je Kaplan-Meier krivulja sveukupnog preživljavanja.
Od ukupno 90 pacijentica, 78 ih je bilo cenzurirano u vremenu od 60 mjeseci. Sva tri parametra pratila su sličan trend u
sveukupnom preživljavanju. PLR nije pokazao statistički značajnu povezanost ni s jednim promatranim fizičko-patološkim
faktora. Dobiveni podaci pokazali su da je u našem slučaju povećana vrijednost SII-a povezana s nižim tumorskih stadijem kao i
vrijednost NLR-a. Dobiveni rezultati u ovom diplomskom radu razlikuju se od rezultata u promatranim istraživačkim radovima.
Razlika u rezultatima može se objasniti malim brojem ispitanika i velikoj heterogenosti promatrane grupe.

Abstract (english)

Because of the high incidence and mortality rates of breast cancer, it is important to investigate markers that can help in the early diagnosis and monitoring of carcinomas. New parameters for monitoring breast cancer that are being investigated are NLR, SII and PLR. NLR is the ratio of neutrophils to lymphocytes. It can be calculated as the ratio of the absolute number of neutrophils and lymphocytes or as the ratio of the percentage of neutrophils and lymphocytes. PLR is the ratio of platelet to lymphocyte count. The systemic immune-inflammatory index (SII) is determined based on NLR and platelet count. It is calculated as the product of NLR and platelet count. The aim of this study was to examine the association between new predictive markers and different tumor characteristics in patients prior to chemotherapy. Retrospective collection of data obtained from patient findings was used as a method. The period of collected data is from 2015 to 2021. Data collected during this period are age of patients, number of neutrophils, lymphocytes, platelets and leukocytes and molecular subtype of breast cancer, tumor stage, lymph node status, histological grade, vascular invasion status, estrogen and progesterone receptor status, HER-2 status and the percentage of Ki-67. The established limit values for the stated parameters were: NLR 2.13, PLR 88.23 and SII 547. Statistically significant P-value was obtained for PLR and SII and tumor stage, while for other parameters no statistically significant P-value was determined. A Kaplan-Meier overall survival curve was performed for all three hematological parameters. Out of a total of 90 patients, 78 were censored over a period of 60 months. All three parameters followed a similar trend in overall survival. PLR did not show a statistically significant association with any of the observed physico-pathological factors. The obtained data showed that in our case the increased SII value was associated with a lower tumor stage as well as the NLR value. The results obtained in this thesis differ from the results in the observed research papers. The difference in the results can be explained by the small number of patients and the large heterogeneity of the observed group.

• Keywords: NLR; SII; PLR; fizičko-patološki faktori; karcinom dojke
• Keywords (english): NLR; SII; PLR; physico-pathological factors; breast cancer
• Language: croatian
• URN:NBN: urn:nbn:hr:163:701010
• Study programme: Title: Medical biochemistry; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: magistar/magistra medicinske biokemije i laboratorijske medicine (magistar/magistra medicinske biokemije i laboratorijske medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2022-02-04 12:52:11