| Abstract | Cilj istraživanja:
Cilj ovog rada je pregledom dostupne znanstvene i stručne literature utvrditi mogućnost
oralne i topikalne primjene probiotika u očuvanju zdravlja kože te njihovu primjenu u
liječenju kožnih bolesti uzimajući u obzir specifičnosti pojedinih probiotičkih vrsta/sojeva.
Materijali i metode:
Za potrebe ovog rada korišteni su podaci kliničkih studija, metaanaliza i preglednih članaka
dobiveni pretraživanjem baza podataka: PubMed (Medline), Elsevier Science Direct, Scopus,
Embase i Cochrane Library prema ključnim riječima (i njihovim kombinacijama): acne,
atopic dermatitis, control of quality, dermatology, microbiom, prebiotics, probiotics,
psoriasis, rosacea, skin reactivity, stability testing, topical probiotic.
Rezultati:
Oralna suplementacija probioticima kod odraslih pacijenata i djece sa dijagnozom atopijskog
dermatitisa pokazala se povoljnom u poboljšanju kliničkih simptoma kao što su osjećaj
svrbeža, suha, gruba i ispucala koža. Perinatalna i postnatalna oralna suplementacija
probioticima rizičnih majki i njihove djece pokazala se dobrim izborom u prevenciji nastanka
atopijskog dermatitisa/ekcema i alergije na hranu. Oralno primjenjeni probiotici u kombinaciji
sa antibiotskom terapijom kod liječenja akni, ispoljavaju protuupalni učinak te smanjuju
nuspojave antibiotske terapije. Kod pacijenata sa dijagnozom psorijaze oralno primijenjeni
probiotici poboljšavaju kliničke simptome bolesti, moduliraju sastav mikrobiote i smanjuju
rizik relapsa bolesti. Topikalno primijenjeni probiotici povećavaju koncentracije ceramida u
epidermi i djeluju protuupalno smanjujući osjećaj svrbeža i suhoće kože. Primijenjeni kod
akni smanjuju broj inflamatornih lezija, a kod rana ubrzavaju proces cijeljenja rana potičući
stvaranje vezivnog tkiva i održavajući ravnotežu kožne mikrobiote.
Zaključak:
Prema rezultatima većeg broja kliničkih studija, oralnom i topikalnom primjenom probiotika
ostvaruju se pozitivni učinci u upalnim stanjima kože. Obzirom da se radi o studijama
rađenim na manjem broju ispitanika te su u navedenim istraživanjima obuhvaćene različite
vrste i sojevi probiotika u različitim dozama, razina dokaza o učinkovitosti je niska. Stoga još
uvijek ne postoje službene smjernice za primjenu probiotika u dermatologiji i potrebna su
dodatna istraživanja kako bi se utvrdila razina djelotvornosti pojedinih sojeva kao i optimalni
režimi doziranja u određenim indikacijama. |
| Abstract (english) | Objectives:
The aim of this study was to review available literature data to determine the possibility of
oral and topical application of probiotics in maintaining skin health and treatment of skin
diseases, with special reference to particular probiotic strains.
Materials and methods:
For the purposes of this study, clinical studies, meta-analyzes and review articles were used.
Data were obtained by searching the following databases: PubMed (Medline), Elsevier
Science Direct, Scopus, Embase, and the Cochrane Library according to keywords (and their
combinations): acne, atopic dermatitis, control of quality, dermatology, microbiom,
prebiotics, probiotics, psoriasis, rosacea, skin reactivity, stability testing, topical probiotic.
Results:
Oral probiotic supplementation in adult patients and children diagnosed with atopic dermatitis
has been shown to be beneficial in improving clinical symptoms such as itchy, dry, rough, and
cracked skin. Perinatal and postnatal oral probiotic supplementation of high-risk mothers and
their children has been shown to be a good choice in the prevention of atopic dermatitis /
eczema and food allergies. Orally administered probiotics in combination with antibiotic
therapy in the treatment of acne resulted in anti-inflammatory effect and reduced the side
effects of antibiotic therapy. In patients diagnosed with psoriasis probiotics improve clinical
symptoms, modulate microbiota composition and reduce the risk of disease relapse. Topically
applied probiotics increased the level of ceramides in the epidermis of atopics and reduced
inflammation, itching and dryness of the skin. Used in acne, toppicaly applied probiotics
reduced the number of inflammatory lesions. They also accelerated the process of wound
healing, by contributing to the formation of connective tissue and maintaining the balance of
the skin microbiota.
Conclusion:
Some clinical studies shows that orally and topically applied probiotics excert positive effects
in inflammatory skin conditions. Nevertheless, it should be taken into account that these are
relatively small clinical trials that investigated the efficiency of different probiotic strains in
different doses. Therefore the level of evidence for the efficiency of probiotics in skin
diseases is low and there are still no official clinical guidelines for the use of probiotics in
dermatology. Additional research is needed to determine the effectiveness of particular strains
in adequate dosage regimes in maintaining skin health and treating different skin conditions. |
