Uloga ceramida u održavanju i obnovi epidermalne barijere

professional thesis

• Author: Danijela Kondža
• Mentor: Jelena Filipović-Grčić (mentor)
• Committee member: Jelena Filipović-Grčić (predsjednik povjerenstva)
• Committee member: Vesna Bačić Vrca (član povjerenstva)
• Committee member: Ivana Čepelak (član povjerenstva)
• Granter: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of pharmaceutical technology); Zagreb
• Defense date and country: 2022, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract

Koža je najveći ljudski organ i njezina glavna uloga je zaštita organizma od vanjskih utjecaja i sprečavanje gubitka vode i elektrolita. Najgornji sloj kože, stratum corneum, predstavlja prvu crtu barijerne funkcije kože. Ceramidi, masne kiseline i kolesterol tvore ekstracelularni lipidni matriks epidermalne barijere i složeni su u guste ortorombske strukture unutar instersticija stratum corneuma. Ceramidi igraju glavnu ulogu u održavanju tih struktura tako da samo male promjene u sastavu i/ili količini ceramida rezultiraju poremećajem barijerne funkcije kože što dovodi do dehidracije kože, povećane propusnosti te u konačnici može dovesti i do patoloških stanja. Ceramidi osim strukturalne uloge djeluju i kao bioaktivni glasnici te igraju mnoge uloge u imunološkom odgovoru kože. Zbog spoznaje da topikalno primjenjeni egzogeni ceramidi povoljno utječu na funkciju i izgled kože, da nisu toksični te da imaju veliku podnošljivost, kozmetički brandovi počeli su ih koristiti u svojim formulacijama za suhu kožu i obnovu kožne barijere. Cilj ovog rada je dati sustavni pregled znanja o strukturi i funkciji glavnih lipida kožne barijere - ceramidima, o načinu formiranja lipidnih membrana rožnatog sloja i o njihovoj molekularnoj organizaciji te dati pregled dostupnih dermatokozmetičkih pripravaka s ceramidima za održavanje i obnovu kožne barijere.

Abstract (english)

Skin is the largest human organ and its main role is to protect the organism from external factors and to prevent water and electrolyte loss. The uppermost layer of skin, the stratum corneum, represents the first line of the skin's barrier function. Ceramides, fatty acids and cholesterol form the extracellular lipid matrix of the epidermal barrier and are packed into thick orthorhombic structures within the interstitium of the stratum corneum. Ceramides play the main role in maintaining these structures, so even small changes in the composition and/or the amount of ceramides result in the impairment of the skin barrier function, which leads to skin dehydration and increased permeability, which in turn can lead to pathological states. Except their structural role, ceramides also act as bioactive messengers and play many roles in the skin's immune response. Since it has been observed that topically applied exogenous ceramides benefit the function and the appearance of the skin, are not toxic and that they have a great tolerability, cosmetic brands have started using them in their formulations for dry skin and for skin barrier restoration. The aim of this paper is to give a systematic overview of the structure and the function of the main skin barrier lipids- ceramides, the formation of the lipid membranes of the horny layer and their molecular organisation, as well as to give an overview of available dermatocosmetic products containing ceramides for the maintenance and restoration of the skin barrier.

• Keywords: barijerna funkcija kože; stratum corneum; ceramidi; egzogeni ceramidi
• Keywords (english): skin's barrier function; stratum corneum; ceramides; exogenous ceramides
• Language: croatian
• URN:NBN: urn:nbn:hr:163:880549
• Study programme: Title: Dermopharmacy and cosmetology; Study programme type: university; Study level: postgraduate specialist; Academic / professional title: sveučilišni magistar/sveučilišna magistra dermofarmacije i kozmetologije (sveučilišni magistar/sveučilišna magistra dermofarmacije i kozmetologije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2022-03-23 16:49:25