Utjecaj topikalne primjene hijaluronske kiseline na izgled i zdravlje kože

professional thesis

• Author: Sanja Trivunović
• Mentor: Marijana Zovko Končić (mentor)
• Committee member: Željka Vanić (predsjednik povjerenstva)
• Committee member: Marijana Zovko Končić (član povjerenstva)
• Committee member: Ines Sjerobabski Masnec (član povjerenstva)
• Granter: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of pharmacognosy); Zagreb
• Defense date and country: 2022-09-05, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract

Cilj istraživanja
Hijaluronska kiselina (HA) je hidrofilni polisaharid glikozaminoglikanske strukture koji igra
višestruku ulogu u regulaciji različitih bioloških procesa i održavanju homeostaze u tijelu. Cilj
ovog specijalistikog rada je procjena utjecaja topikalne primjene HA na izgled i zdravlje kože.
Materijali i metode
Za potrebe izrade ovog teorijskog specijalističkog rada, pretražene su baze podataka
znanstvenih radova te drugi znanstveni izvori i mrežne stranice sa srodnom tematikom.
Pretraživanjem su se obuhvatile kliničke studije koje su ispitale učinak HA na procese koji
utječu na izgled i zdravlje kože te in vitro i in vivo studije koje objašnjavaju mehanizme
opaženih učinaka.
Rezultati
Zbog svojih higroskopnih značajki HA djeluje hidratantno, usporava starenje kože, ubrzava
zacjeljivanje opeklina i drugih rana. Veličina molekula HA značajno utječe na dubinu njezine
penetracije u kožu, kao i antiaging svojstva topikalnih hijaluronskih pripravaka. HA značajno
povećava hidrataciju kože, a pozitivno utječe i na elastičnost i tonus kože te smanjenje bora.
Tehnološkim postupcima poput mikronizacije, uklapanjem u liposome i nanočestice te
kombinacijom s glicerolom, ekstraktom vrste Centella asiatica, N-acetil glukozaminom, gamaamino
maslačnom kiselinom te ljudskim faktorom rasta može se povećati učinak HA na izgled
i zdravlje kože. U kliničkim studijama HA se pokazala učinkovitom u zacjeljivanju različitih
vrsta rana poput opeklina, dijabetičkog ili venskog ulkusa, a dobar učinak HA na zacjeljivanje
rana uočen je i u kombinaciji HA sa srebro-sulfatiazinom ili ionima srebra. Nekoliko studija je
potvrdilo da topikalna primjena HA niske molekularne mase, rezultira poboljšanjem simptoma
dermatitisa, rozacee i strija.
Zaključak
Topikalna primjena HA doprinosi zdravlju kože i usporava proces starenja. HA pokazuje
blagotvorne i pozitivne učinke u terapiji brojnih kožnih bolesti i stanja. Brojne studije potvrđuju
učinkovitost HA u kozmetikoj i dermatološkoj primjeni.

Abstract (english)

Objectives
Hyaluronic acid (HA) is a hydrophylic polysaccharide of glycosaminoglycan type that plays
various roles in human organism, including regulation od various biological processes and
maintenance of homeostasis. The aim of this specialist paper is to assess the impact of topical
application of HAon the appearance and health of the skin.
Material and methods
For the purposes of preparing this theoretical specialist paper, scientific databases papers and
other with scientific sources and web sites with related topics were searched. The study
included clinical studies examining the effect of HA on processes affecting skin appearance
and health, as well as in vitro and in vivo studies explaining the mechanisms of the observed
effects.
Results
Due to its hygroscopic features, HA acts as moisturizer, slows down the aging of the skin, and
accelerates the healing of burns and other wounds. The size of HA molecules significantly
affects the depth of its penetration into the skin, as well as the antiaging characteristics of topical
hyaluronic preparations. HA significantly increases skin hydration and has a positive effect on
skin elasticity and tone, as well as wrinkle reduction. Technological procedures such as
micronization, encapsulation in liposomes or nanoparticles as well as combination with
glycerol, Centella asiatica extract, N-acetyl glucosamine, gamma-amino butyric acid and
human growth factor may increase the effect of HA on skin appearance and health. In clinical
studies, HA has proven to be an effective agent for healing of several types of wounds such as
burns, diabetic or venous ulcers.Beneficial effect of HA on wound healing has also been
observed in combination of HA with silver sulfatiazine or silver ions. Several studies have
confirmed that topical use low molecular weight HA results in an improvement in the symptoms
of dermatitis, rosacea and stretch marks.
Conclusion
Topical use of HA contributes to skin health and slows down the aging process. HA shows
beneficial and positive effects in the therapy of numerous skin diseases and conditions.
Numerous studies confirm the effectiveness of HA in cosmetic and dermatological application.

• Keywords: hijaluronska kiselina; hijaluronat; koža; topikalna primjena
• Keywords (english): hyaluronic acid; hyaluronate; skin; topical application
• Language: croatian
• URN:NBN: urn:nbn:hr:163:592368
• Study programme: Title: Dermopharmacy and cosmetology; Study programme type: university; Study level: postgraduate specialist; Academic / professional title: sveučilišni magistar/sveučilišna magistra dermofarmacije i kozmetologije (sveučilišni magistar/sveučilišna magistra dermofarmacije i kozmetologije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2022-09-09 13:41:42