Utjecaj probiotika na funkcionalnu konstipaciju u osoba starije životne dobi

doctoral thesis

• Title (english): The effect of probiotics on functional constipation in the elderly
• Author: Katarina Fehir Šola
• Mentor: Donatella Verbanac (mentor)
• Mentor: Sanda Vladimir-Knežević (komentor)
• Committee member: Vesna Bačić Vrca (predsjednik povjerenstva)
• Committee member: Ana-Maria Šimundić (član povjerenstva)
• Committee member: Blaženka Kos (član povjerenstva)
• Granter: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of medical biochemistry and haematology); Zagreb
• Defense date and country: 2022-01-13, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy
• Universal decimal classification (UDC): 615 - Pharmacology. Therapeutics. Toxicology

Abstract

Konstipacija je jedna od najčešćih kroničnih gastrointestinalnih tegoba. Dosadašnja klinička istraživanja upućuju
na zaključak da probiotici mogu poboljšati stanje osoba koje pate od konstipacije. Stoga je cilj ovog istraživanja
bio ispitati utjecaj odabranih sojeva probiotika na funkcionalnu konstipaciju osoba starije životne dobi smještenih
u domu za starije i nemoćne, koristeći randomizirani, dvostruko slijepi, placebom kontrolirani, paralelni dizajn
studije. Sudionici u studiji s probioticima su randomizirani u dvije skupine kroz 12 tjedana intervencije s
probiotičkim sojevima Bifidobacterium animalis subsp. lactis BLC1, Lactobacillus acidophilus LA 3,
Lactobacillus casei BGP93 ili placebom. Primarni cilj bio je ispitati učinak odabranih probiotičkih sojeva na broj
dnevnih stolica tijekom 12 tjedana. Sekundarni ciljevi istraživanja obuhvatili su procjenu učinka odabranih
probiotičkih sojeva na biljege upale, pokazatelje metabolizma glukoze i lipida, jetrene enzime i druge
laboratorijske parametre kompletne krvne slike, kao i učinka ljekarničkih intervencija na poboljšanje terapijskih
ishoda i kvalitete života osoba starije životne dobi s funkcionalnom konstipacijom smještenih u domu za starije i
nemoćne osobe. Nakon 12 tjedana tretmana kontinuirano se povećavao kumulativni broj stolica u usporedbi s
placebom, ali bez statističke značajnosti. No, isključenjem podataka o broju stolica u dane kad je evidentirana
primjena laksativa, statistička značajnost se dostigla 71. dana tretmana. Na krvne parametre nije bilo statistički
značajnih promjena. Ljekarničke intervencije su se pokazale kao važan dio skrbi za osobe starije životne dobi
smještenih u domu za starije i nemoćne.

Abstract (english)

Constipation is a common gastrointestinal complaint. Clinical research suggests that probiotics may improve
people's condition of constipation. Therefore, this study aimed to examine the impact of selected strains of
probiotics on the functional constipation of elderly placed in a nursing home, using a randomized, double-blind,
placebo-controlled, parallel study design. Participants in the probiotic study were randomized into two groups
over 12 weeks of intervention with probiotic strains of Bifidobacterium animalis subsp. lactis BLC1,
Lactobacillus acidophilus LA 3, Lactobacillus casei BGP93 or placebo. The primary objective was to examine
the effect of selected probiotic strains on the number of daily stools over 12 weeks. Secondary objectives of the
study included assessing the effect of selected probiotic strains on markers of inflammation, glucose and lipid
metabolism indicators, liver enzymes and other laboratory parameters of complete blood count, as well as the
effect of pharmacy interventions on improving therapeutic outcomes and quality of life of elderly with functional
constipation in a nursery home. After 12 weeks of treatment, the cumulative stool count increased continuously
compared with placebo, but without statistical significance. However, excluding stool count data on days when
laxative use was recorded, statistical significance was reached on day 71 of treatment. There, was no significant
changes in blood parameters. Pharmacy interventions were an essential part of pharmaceutical care in a nursing
home.

• Keywords: probiotici; funkcionalna konstipacija; osobe starije životne dobi; terapijski problemi; ljekarnička skrb
• Keywords (english): probiotics; functional constipation; elderly; therapy problems; pharmaceutical care
• Language: croatian
• URN:NBN: urn:nbn:hr:163:375506
• Promotion: 2022
• Study programme: Title: Pharmacy and biochemistry; Study programme type: university; Study level: postgraduate; Academic / professional title: doktor znanosti (doktor znanosti)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2022-11-07 12:02:57