Suvremena laboratorijska dijagnostika i praćenje šećerne bolesti

master's thesis

• Title (english): Modern laboratory diagnosis and monitoring of diabetes melitus
• Author: Mihaela Marinčić
• Mentor: Roberta Petlevski (mentor)
• Committee member: Roberta Petlevski (predsjednik povjerenstva)
• Committee member: Marija Grdić Rajković (član povjerenstva)
• Committee member: Lovorka Vujić (član povjerenstva)
• Granter: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of medical biochemistry and haematology); Zagreb
• Defense date and country: 2023-02-10, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract

Šećerna bolest je heterogena bolest koja dovodi do hiperglikemije. Dugoročne komplikacije bolesti imaju ozbiljne posljedice na zdravlje pacijenta i na troškove u zdravstvenom sustavu. Važno je bolest rano dijagnosticirati, liječiti i kontrolirati. Dijagnoza se postavlja na temelju vrijednosti glukoze u venskoj plazmi natašte, koncentracije u venskoj plazmi 2 sata nakon opterećenja glukozom, vrijednosti slučajne glukoze u plazmi uz prisutne simptome te na temelju vrijednosti HbA1c. Razlikujemo i stanja poremećene glukoze natašte i poremećene tolerancije glukoze kada vrijednosti glukoze još ne označavaju dijabetes, ali su previsoke da bi ih smatrali normalnima. Kontrola glikemije se vrši mjerenjem HbA1c, samokontrolom glukoze u krvi i kontinuiranim praćenjem glukoze. HbA1c je standardi biomarker kontrole glikemije i ukazuje na prosječnu glikemiju posljednjih 120 dana. Samokontrolu glukoze u krvi ponajviše koriste pacijenti koji su na terapiji inzulinom te se koristi više puta dnevno. Kontinuirano praćenje glukoze omogućava praćenje koncentracije i trenda kretanja glukoze u stvarnom vremenu. Iz kontinuiranog praćenja glukoze se dobiva mnogo informacija koje se objedinjuju ambulantnim profilom glukoze te omogućuju personaliziranim plan liječenja dijabetesa. Kako bi se bolest ranije dijagnosticirala te kako bi praćenje bolesti bilo što uspješnije istražuju se i drugi markeri kao što su mikroRNA, suzni film, proteini nokta, slina.

Abstract (english)

Diabetes is a heterogeneous disease that leads to hyperglycemia. Long-term complications of the disease have serious consequences on the patient's health and on costs in the health care system. It is important to diagnose, treat and control the disease early. The diagnosis is made on the basis of glucose values in the fasting venous plasma, the concentration in the venous plasma 2 hours after the glucose load, the random glucose values in the plasma with the present symptoms and on the basis of the HbA1c value. We also distinguish between impaired fasting glucose and impaired glucose tolerance when glucose values do not yet indicate diabetes, but are too high to be considered normal. Glycemic control is performed by measuring HbA1c, self-monitoring of blood glucose and continuous glucose monitoring. HbA1c is the standard biomarker of glycemic control and indicates the average glycemia of the last 120 days. Self-monitoring of blood glucose is mostly used by patients who are on insulin therapy and is used several times a day. Continuous glucose monitoring enables monitoring of the concentration and trend of glucose in real time. A lot of information is obtained from continuous glucose monitoring, which is combined into an ambulatory glucose profile and enables a personalized diabetes treatment plan. In order to diagnose the disease earlier and to make the monitoring of the disease as successful as possible, other markers such as microRNA, tear film, nail proteins, and saliva are also being investigated.

• Keywords: dijabetes; šećerna bolest; dijagnostika; HbA1C; SMBG; CGM
• Keywords (english): diabetes; monitoring; HbA1C; SMBG; CGM
• Language: croatian
• URN:NBN: urn:nbn:hr:163:056642
• Study programme: Title: Pharmacy; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: magistar/magistra farmacije (magistar/magistra farmacije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2023-02-14 14:52:07