Determination of naphthoquinones in invasive alien plants Impatiens glandulifera Royle and I. balfourii Hook.f. from Croatia

Scientific paper - Original scientific paper

• Author: Željan Maleš
• Author: Ana-Marija Domijan
• Author: Ivan Duka
• Author: Tihana Marić
• Author: Mirza Bojić
• Author: Hrvoje Rimac
• Author: Božena Mitić
• Author: Dario Hruševar
• Author: Karmela Barišić
• Author: Donatella Verbanac
• Author's institution: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of pharmaceutical botany)
• Author's institution: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of medicinal chemistry)
• Author's institution: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of medical biochemistry and haematology)
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract (english)

The study aimed to develop an HPLC method for a simultaneous determination of 2-hydroxy-1,4-naphthoquinone (2-HNQ) and 2-methoxy-1,4-naphthoquinone (2-MNQ) in plant material. The method was implemented to determine naphthoquinones (NQs) in leaves and flowers of the invasive alien species Impatiens glandulifera and I. balfourii collected in Croatia. Two NQs extraction methods from plant material were compared: decoction and ultrasonic extraction. Validation parameters indicate that the developed method is reliable for the simultaneous determination of 2-HNQ and 2-MNQ in plant material. The decoction extraction obtained a higher NQs yield than ultrasonic extraction. In the leaves and flowers of I. glandulifera and I. balfourii only 2-MNQ was detected. Both, I. glandulifera and I. balfourii, had higher 2-MNQ concentrations in flowers than in leaves. A significantly higher 2-MNQ concentration was found in I. glandulifera compared to I. balfourii. Therefore, I. glandulifera can be considered a rich source of 2-MNQ whose antitumor potential is established.

• Keywords (english): invasive alien species; 2-hydroxy-1,4-naphthoquinone; 2-methoxy-1,4-naphthoquinone; novel therapeutics; HPLC
• Language: english
• Publication type: Scientific paper - Original scientific paper
• Publication status: Published
• Peer review: Peer review - international
• Publication version: Published version
• Journal title: Croatica Chemica Acta
• Numbering: vol. 95, no. 1, pp. 1-5
• p-ISSN: 0011-1643
• e-ISSN: 1334-417X
• DOI: https://doi.org/10.5562/cca3911
• URN:NBN: urn:nbn:hr:163:939856
• Publication: 2022
• Document URL: https://hrcak.srce.hr/286205
• Type of resource: Text
• Access conditions: Open access
• Created on: 2023-03-09 13:31:32