Farmakološke karakteristike diuretika i njihova zlouporaba

master's thesis

• Title (english): The pharmacological characteristics of diuretics and their misuse
• Author: Antonela Tolić
• Mentor: Lidija Bach-Rojecky (mentor)
• Committee member: Lidija Bach-Rojecky (predsjednik povjerenstva)
• Committee member: Sandra Šupraha-Goreta (član povjerenstva)
• Committee member: Živka Juričić (član povjerenstva)
• Granter: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of pharmacology); Zagreb
• Defense date and country: 2023-03-10, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract

Diuretici su lijekovi koji smanjuju volumen ekstracelularne tekućine povećavanjem izlučivanja soli i vode putem bubrega. Međusobno se razlikuju po strukturi, fizikalno-kemijskim svojstvima, mehanizmu i mjestu djelovanja zbog čega se svrstavaju u nekoliko skupina. Raznolikost diureticima omogućava široku primjenu za niz indikacija, kao što su arterijska hipertenzija i srčano zatajivanje. Međutim, zbog brzog smanjenja kilograma i prikrivanja prisutnosti drugih zabranjenih supstanci, često se koriste kao doping sredstvo u sportu. Nalaze se na Listi zabranjenih supstanci Svjetske antidoping agencije više od 30 godina te je njihova upotreba zabranjena i u samom natjecanju i izvan natjecanja. Posljedice njihove nekontrolirane primjene s jedne strane mogu biti stroge kazne koje mogu značajno obiljeţiti karijeru sportaša, a s druge strane direktni nepovoljni učinci na organizam sportaša te je potreban veliki oprez kod (zlo)upotrebe diuretika.

Abstract (english)

Diuretics are drugs that reduce volume of extracellular fluid by increasing the excretion of salt and water by the kidneys. They can be differentiated by structure, physical and chemical properties, mechanism, together with, the place of action, which is why we classify them in several groups. The diversity of diuretics enables wide application for a number of indications such as arterial hypertension and heart failure. However, due to the rapid weight loss and the concealment of the presence of other prohibited substances, they are often used as a doping agent in sports. They have been on the List of Prohibited Substances of the World Anti-Doping Agency for more than 30 years, and their use is prohibited both in and out of competition. Aftermath of uncontrolled intake and usage of diuretics can result in severe penalties that can significantly and negatively mark an athlete´s career, as well as direct adverse effect they have on the athlete´s body, and it is necessary to be weary and precautious when (mis)using diuretics.

• Keywords: diuretici; maskirajući agensi; sport; doping
• Keywords (english): diuretics; masking agents; sport; doping
• Language: croatian
• URN:NBN: urn:nbn:hr:163:249090
• Study programme: Title: Pharmacy; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: magistar/magistra farmacije (magistar/magistra farmacije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2023-03-13 11:46:59