Ultrazvučna ekstrakcija biološki aktivnih spojeva iz vrste Plantago major L.

master's thesis

• Title (english): Ultrasound extraction of biologically active compounds from Plantago major L
• Author: Patricia Štriga
• Mentor: Marijana Zovko Končić (mentor)
• Committee member: Marijana Zovko Končić (predsjednik povjerenstva)
• Committee member: Dubravka Vitali Čepo (član povjerenstva)
• Committee member: Maja Bival Štefan (član povjerenstva)
• Granter: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of pharmacognosy); Zagreb
• Defense date and country: 2023-07-10, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract

U ovom radu je bila provedena ultrazvučna ekstrakcija raznih polifenola iz širokolisnog trputca
(Plantago major L.) mijenjajući uvjete ekstrakcije. Mijenjana je temperatura, snaga ultrazvuka te
sastav ekstrakcijskog otapala. Ekstrakcijsko otapalo je bilo priređeno s glicerolom, vodom i
mliječnom kiselinom varirajući udio pojedinih sastavnica. Rezultati su pokazali varijabilnost u
uspješnosti i iskorištenju ekstrakcije ovisno o sastavu ekstrakcijskog otapala i strukturi promatranog
polifenola. Kod većine spojeva je ekstrakcija bila uspješnija uz veći udio glicerola i mliječne kiseline
te povećanjem temperature i snage ultrazvuka. Iznimke su bile flavonoidi i feniletanoid verbaskozid
kojima je pogodovao manji udio glicerola te iridoid aukubin koji je osjetljiv na kiseline i visoku
temperaturu.

Abstract (english)

In this study, ultrasonic extraction of various polyphenols from broad-leaved plantain (Plantago
major L.) was carried out by variation of extraction parameters. The temperature, ultrasound
power and composition of the extraction solvent were changed. The extraction solvent was
prepared with glycerol, water, and lactic acid, varying the proportion of individual components.
The results show variability in the success and utilization of the extraction depending on the
composition of the extraction solvent and the structure of the observed polyphenol. For most
compounds, the extraction was more successful with a higher proportion of glycerol and lactic
acid and by increasing the temperature and ultrasound power. The exceptions were flavonoids
and phenylethanoid verbascoside, which benefited from a lower proportion of glycerol, and
iridoid aucubin, which is sensitive to acids and high temperatures.

• Keywords: širokolisni trputac; polifenoli; fenolne kiseline; flavonoidi; aukubin; verbaskozid; ultrazvučna ekstrakcija
• Keywords (english): plantain; polyphenols; phenolic acids; flavonoids; aucubin; verbascoside; ultrasound extraction
• Language: croatian
• URN:NBN: urn:nbn:hr:163:024750
• Study programme: Title: Pharmacy; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: magistar/magistra farmacije (magistar/magistra farmacije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Embargoed access; Embargo expiration date: 2025-07-10
• Created on: 2023-11-07 14:14:56