Fizikalno-kemijska karakterizacija dodataka prehrani koji se koriste u terapiji upalnih bolesti crijeva

master's thesis

• Title (english): Physicochemical characterization of dietary supplements used in the therapy of inflammatory bowel diseases
• Author: Matea Perko
• Mentor: Ana Mornar Turk (mentor)
• Committee member: Ana Mornar Turk (predsjednik povjerenstva)
• Committee member: Marijana Zovko Končić (član povjerenstva)
• Committee member: Ana-Marija Domijan (član povjerenstva)
• Granter: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of pharmaceutical analysis); Zagreb
• Defense date and country: 2023-06-07, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract

Upalne bolesti crijeva skupina su autoimunih bolesti koje karakterizira kronično ili relapsno upalno stanje u
gastrointestinalnom traktu. Zabrinjava rast incidencije i prevalencije ovih bolesti u općoj populaciji jer ozbiljno
narušavaju kvalitetu života pacijenata i predstavljaju brojne izazove za zdravstvo. Zbog izazovnog i
dugotrajnog liječenja, pacijenti s upalnim bolestima crijeva nerijetko posežu za dodacima prehrani. Kako je
broj pacijenata koji koriste dodatke prehrani u porastu, u fokus dolazi pitanje kontrole kvalitete dodataka
prehrani.
Cilj ovoga rada bio je prema USP protokolima provesti fizikalno-kemijsku karakterizaciju biljnih dodataka
prehrani koji se koriste u terapiji upalnih bolesti crijeva.
Ispitivano je 36 uzoraka u različitim dozirnim oblicima: tablete, prašci, tvrde capsule i meke kapsuse.
Provedena su sljedeća ispitivanja: ispitivanje nasipne gustoće i gustoće nakon protresivanja (USP<616>),
varijacije mase dozirnih oblika (USP <2091>), raspadljivosti (USP <2040>), pucanja mekih kapsula (USP
<2040>), rastrošljivosti tableta (USP <1216>) i ispitivanje sile loma tableta (USP <1217>). Najbolja svojstva
tečenja prema nasipnoj gustoći nakon protresivanja među ispitivanim uzorcima prašaka imaju sirovine
kurkume, a najlošija uzorci andrografisa. Sve ispitivane tablete i kapsule zadovoljile su kriterij USP-a u
ispitivanju varijacije mase. Samo jedan uzorak nije zadovoljio kriterij raspadljivosti. U ispitivanju pucanja
mekih kapsula i rastrošljivosti tableta svi su uzorci zadovoljili USP kriterije. Sila loma ispitivanih tableta bila
je u rasponu od 27,7 do 248,5N. . Loša svojstva tečenja sirovina mogla bi uzrokovati neujednačenost dozirnih
jedinica, a tableta koja se nije raspala najvjerojatnije neće biti učinkovita in vivo.

Abstract (english)

Text Inflammatory bowel diseases are a group of autoimmune diseases characterized by chronic or relapsing
inflammatory conditions in the gastrointestinal tract. The increasing incidence and prevalence of these
diseases in the general population are concerning because they seriously compromise the quality of life of
patients and present numerous challenges for healthcare Due to the challenging and prolonged treatment,
patients with inflammatory bowel diseases often turn to dietary supplements. As the number of patients using
these supplements is growing, it is important to investigate their effectiveness and safety.
The aim of this work was to conduct a physicochemical characterization of herbal dietary supplements used
in the therapy of inflammatory bowel diseases according to the USP protocols.
36 samples were tested in various dosage forms: tablets, powders, hard capsules and soft capsules. The
following tests were carried out: bulk density and tapped density (USP <616>), weight variation of dosage
forms (USP <2091>), disintegration (USP <2040>), soft capsule rupture (USP <2040>), tablet friability (USP
<1216>) and tablet breaking force (USP <1217>).The raw materials of turmeric have the best flow properties,
according to tapped density testing, among the tested powder samples, while the andrographis samples have
the least desirable flow properties. All tested tablets and capsules passed the USP weight variation test. Only
one sample did not meet the disintegration criteria. In the soft capsule rupture and tablet friability testing, all
samples met the USP criteria. Tablet breaking force was in the range from 27.7 to 248.5N. Poor raw material
flow characteristics can cause unequal dosing units, while a tablet that did not disintegrate is unlikely to be
effective in vivo.

• Keywords: upalne bolesti crijeva; farmakopeja; dodaci prehrani
• Keywords (english): inflammatory bowel disease; pharmacopeia; dietary supplements
• Language: croatian
• URN:NBN: urn:nbn:hr:163:929744
• Study programme: Title: Pharmacy; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: magistar/magistra farmacije (magistar/magistra farmacije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2024-01-18 13:35:59