Fizikalno-kemijska svojstva farmaceutika otkrivenih u rijeci Cetini i na izvoru rijeke Jadro

master's thesis

• Title (english): Physicochemical properties of pharmaceuticals discovered in the Cetina River and at the source of the Jadro River
• Author: Samanta Šubić
• Mentor: Valerije Vrček (mentor)
• Committee member: Valerije Vrček (predsjednik povjerenstva)
• Committee member: Davor Šakić (član povjerenstva)
• Committee member: Erim Bešić (član povjerenstva)
• Granter: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of organic chemistry); Zagreb
• Defense date and country: 2023-09-28, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract

Farmaceutici i proizvodi za osobnu njegu (PPCP's) detektirani su na rijeci Cetini i izvoru Jadro.
U rijeci Cetini je uočena pojava analgetika (ibuprofen, acetaminofen i kofein) i antidijabetika meformina, dok su na
izvoru rijeke Jadro detektirani antiepileptici (karbamazepin i lamotrigin), opioidni analgetik (tramadol),
antihipertenziv (valsartan), antimikotik (klimbazol), antibiotik (sulfametoksazol) i lijek za liječenje ovisnosti o
nikotinu (kotinin). Koristeći EPI Suite™ i ACD/Labs Percepta platforme dobiveni su fizikalno-kemijski parametri
pomoću kojih su uspoređena svojstva PPCP-ova i njihovih sudbina u okolišu. Među različitim fizikalno-kemijskim
parametrima lociranih i ispitivanih lijekova ističu se koeficijent adsorpcije na tlo (KOC), konstanta brzine
fotokemijske reakcije kOH i parametar anaerobne razgradnje kao razlikovni indikatori na temelju kojih je moguće
objasniti klasterizaciju lijekova u rijeci Cetini i na izvoru rijeke Jadro.

Abstract (english)

Pharmaceuticals and personal care products (PPCP's) were detected in the Cetina River and the Jadro spring.
Analgesics (ibuprofen, acetaminophen and caffeine) and antidiabetic meformin were observed in the Cetina River,
while antiepileptics (carbamazepine and lamotrigine), opioid analgesic (tramadol), antihypertensive (valsartan),
antimycotic (climbazol), antibiotic (sulfamethoxazole) and a drug for the treatment of nicotine addiction (cotinine).
Using EPI Suite™ and the ACD/Labs Percepta platform, physico-chemical parameters were obtained, which were
used to compare the properties of PPCP's and their fates in the environment. Among the different physicochemical
parameters of the drugs located and tested, the soil adsorption coefficient (KOC), the rate constant of the
photochemical reaction kOH and the anaerobic decomposition parameter stand out as specific indicators. Using these
indicators it is possible to explain the clustering of drugs in the Cetina River and at the source of the Jadro River.

• Keywords: nova onečišćivala; farmaceutici i proizvodi za osobnu njegu (PPCP's); krški izvori; Jadro; Cetina; EPISUITE; fotorazgradnja; anaerobna biorazgradnja
• Keywords (english): emerging contaminants; pharmaceuticals and personal care products (PPCP's); karst spring; Jadro; Cetina; EPISUITE; photodegradation; anaerobic biodegradation
• Language: croatian
• URN:NBN: urn:nbn:hr:163:931975
• Study programme: Title: Pharmacy; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: magistar/magistra farmacije (magistar/magistra farmacije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2024-01-22 14:06:38