Stres i gastrointestinalni sustav: patofiziologija i mogućnosti liječenja

master's thesis

• Title (english): Stress and the gastrointestinal system: pathophysiology and treatment options
• Author: Marina Nakić
• Mentor: Kristina Radić (mentor)
• Committee member: Kristina Radić (predsjednik povjerenstva)
• Committee member: Dubravka Vitali Čepo (član povjerenstva)
• Committee member: Andrea Brajković (član povjerenstva)
• Granter: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of food chemistry); Zagreb
• Defense date and country: 2023-07-10, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract

Stres izaziva značajne poremećaje u gastrointestinalnom sustavu što rezultira pojavom funkcionalnih bolesti poput funkcionalne dispepsije, upalnih bolesti crijeva (ulceroznog kolitisa ili Crohnove bolesti) i sindroma iritabilnog kolona. Iako se farmakoterapija obično koristi kao primarna terapijska metoda za ove bolesti, ona je simptomatska i može imati brojne nuspojave, interakcije s drugim lijekovima i visoke troškove. Ipak, sve veći broj dokaza upućuje na učinkovitost alternativnih mjera u smanjenju utjecaja stresa na gastrointestinalni sustav. Te mjere uključuju primjenu probiotika, prebiotika, transplantaciju fekalne mikrobiote, promjenu obrasca prehrane, kognitivno-bihevioralnu terapiju, mindfulness, akupunkturu, hipnoterapiju i psihoterapiju. No, unatoč sigurnosti i niskim troškovima ovih alternativnih pristupa, često se zanemaruju u svakodnevnoj praksi ljekarničkog savjetovanja.
Napisani diplomski rad opisuje poznate mehanizme kojima stres uzrokuje poremećaje u gastrointestinalnom sustavu, kao i bolesti koje se javljaju kao rezultat dugotrajne izloženosti stresu. Također, u diplomskom radu se obraća pažnja i na alternativne metode za koje postoje dokazi o njihovoj učinkovitosti u liječenju poremećaja GIT-a.
Cilj podrobnog provedenog istraživanja literature kojim je napisan diplomski rad je podići svijest ljekarnika o vezi između stresa i gastrointestinalnog sustava te o alternativnim pristupima koji se mogu primijeniti prilikom savjetovanja pacijenata u ljekarnama s ciljem pružanja cjelovitih informacija vezanih za funkcionalne bolesti GIT-a kao i podršku pacijentima u vezi upravljanjem stresom i očuvanjem zdravlja gastrointestinalnog sustava.

Abstract (english)

Stress causes significant disorders in gastrointestinal tract whitch results in appearance of functional diseases such as functional dyspepsia, inflammatory bowel disease (ulcerative colitis, Chron`s disease) and irritable bowel syndrome. Although pharmacotherapy is usually used as primary therapeutic method in this diseases, it is symptomatic, can cause various side effects, interactions with other drugs and also it is highly priced. However, a growing body of evidence point to effectiveness of alternative measures in reducing the impact of stress on the gastrointestinal system. These measaures include implementation of probiotics, prebiotics, fecal microbiota transplantation, change in diet, cognitive behavioural therapy, mindfulness, acupuncture, hypnotherapy and psychotherapy. However, despite the safety and low costs of these alternative approaches, they are often neglected in the daily practice of pharmacy counseling.
Written thesis describes the known mechanisms by which stress causes disordes in the gastrointestinal system, as well as diseases that occur as the result of long-term exposure to stress. Furthermore, the thesis pays attention to alternative methods for which there is evidence of their effectiveness in the treatment of GIT disorders.
The aim of the detailed literature research used to write this thesis is raising the pharmacists' awareness about the connection between stress and the gastrointestinal system as well about alternative approaches that can be applied when counseling patients in pharmacies with the aim of providing complete information related to functional diseases of the GIT as well as patient support in relation to stress managament and maintaining the health of the gastrointestinal system.

• Keywords: stres; gastrointestinalni sustav; probavni sustav; mozgovno-crijevna os; IBS; IBD; mikrobiota; probiotici; funkcionalna dispepsija
• Keywords (english): stress; gastrointestinal tract; digestive system; brain-gut axis; IBS; IBD; microbiota; probiotics; functional dyspepsia
• Language: croatian
• URN:NBN: urn:nbn:hr:163:940139
• Study programme: Title: Pharmacy - integrated undergraduate and graduate - university study; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: sveučilišni magistar farmacije (sveučilišni magistar farmacije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2024-04-02 11:07:42