Sustavni pregled interakcija dodataka prehrani i lijekova u sekundarnoj terapiji infarkta miokarda temeljen na dokazima

master's thesis

• Title (english): Systematic review of interactions of dietary supplements and drugs used in secondary therapy of myocardial infarction based on evidence
• Author: Lara Vlah
• Mentor: Kristina Radić (mentor)
• Committee member: Kristina Radić (predsjednik povjerenstva)
• Committee member: Dubravka Vitali Čepo (član povjerenstva)
• Committee member: Andrea Brajković (član povjerenstva)
• Granter: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of food chemistry); Zagreb
• Defense date and country: 2024-02-02, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract

Infarkt miokarda predstavlja značajno kardiovaskularno oboljenje s visokom prevalencijom širom
svijeta. U svrhu prevencije ponovnih kardiovaskularnih komplikacija, pacijentima se prepisuje
sekundarna terapija koja obuhvaća širok spektar lijekova, poput β-blokatora, antitrombotika, statina,
ACE-inhibitora, uz istovremenu kontrolu faktora rizika. Uz to, sve češće se primjećuje da pacijenti,
koji su preživjeli infarkt miokarda, mijenjaju svoje životne navike te koriste dodatke prehrani u nadi
poboljšanja općeg zdravstvenog stanja. S obzirom na kompleksnost terapije i sveprisutnu upotrebu
dodataka prehrani, postaje izrazito važno prepoznati moguće interakcije između lijekova i dodataka
prehrani. Upravo farmaceuti igraju ključnu ulogu u prevenciji, prepoznavanju i upravljanju tim
interakcijama kako bi osigurali adekvatnu skrb za pacijente. Stoga ovaj diplomski rad pruža sustavan
pregled interakcija između dodataka prehrani i lijekova korištenih u sekundarnoj terapiji infarkta
miokarda, temeljen na znanstvenim dokazima. Pritom su objašnjeni raznoliki mehanizmi interakcija,
kao što su smanjenje bioraspoloživosti, nefrotoksičnost, hepatoksičnost, te promjene
farmakokinetike lijekova. Ova tema ne samo da je relevantna zbog česte pojavnosti infarkta
miokarda, već i zbog specifičnih izazova koje donosi u ljekarničkoj praksi. Diplomski rad pridonosi
razvoju stručnosti farmaceuta u optimalnom upravljanju terapijom pacijenata nakon infarkta
miokarda, čime se direktno utječe na zdravstveno stanje i kvalitetu života pacijenata.

Abstract (english)

Myocardial infarction is a significant cardiovascular disease with a high prevalence worldwide. In
order to prevent repeated cardiovascular complications, patients are prescribed secondary therapy
that includes a wide range of drugs, such as β-blockers, antithrombotics, statins, ACE-inhibitors,
with simultaneous control of risk factors. In addition, it is increasingly noticed that patients, who
have survived a myocardial infarction, change their lifestyle and use dietary supplements with hope
of improving their general health. Considering the complexity of therapy and the ubiquitous use of
dietary supplements, it becomes extremely important to recognize possible interactions between
drugs and dietary supplements. Pharmacists play a key role in the prevention, recognition and
management of these interactions in order to ensure adequate care for patients. Therefore, this thesis
provides a systematic review of the interactions between dietary supplements and drugs used in the
secondary therapy of myocardial infarction, based on scientific evidence. Various mechanisms of
interactions, such as reduction of bioavailability, nephrotoxicity, hepatotoxicity, and changes in drug
pharmacokinetics were explained. This topic is not only relevant because of the high prevalence of
myocardial infarction, but also because of the specific challenges it brings in pharmaceutical
practice. The diploma thesis contributes to the development of the expertise of pharmacists in the
optimal management of therapy for patients after myocardial infarction, which directly affects their
health status and quality of life.

• Keywords: infarkt miokarda; interakcije; dodaci prehrani; lijekovi; mehanizam; sekundarna terapija
• Keywords (english): myocardial infarction; interactions; dietary supplements; drugs; mechanism; secondary therapy
• Language: croatian
• URN:NBN: urn:nbn:hr:163:600919
• Study programme: Title: Pharmacy - integrated undergraduate and graduate - university study; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: sveučilišni magistar farmacije (sveučilišni magistar farmacije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2024-06-12 13:26:30