Bakuchiol kao funkcionalni analog retinoida: biološki učinci i formulacije

master's thesis

• Title (english): Bakuchiol as a functional retinoid analog: biological effects and formulations
• Author: Vanda Petrak
• Mentor: Zora Rukavina (mentor)
• Committee member: Zora Rukavina (predsjednik povjerenstva)
• Committee member: Petra Turčić (član povjerenstva)
• Committee member: Ivan Pepić (član povjerenstva)
• Granter: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of pharmaceutical technology); Zagreb
• Defense date and country: 2024-03-20, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract

Bakuchiol je prenilirani fenolni monoterpen ekstrahiran iz ploda Cullen corylifolium L., koji pripada porodici biljaka Fabaceae (Leguminosae). Bakuchiol je odobren u zemljama Europske unije kao sigurna komponenta kozmetičkih proizvoda. Cosmetic ingredient database Europske komisije (CosIng) preporučuje ga za upotrebu kao sastojak s antimikrobnim, antioksidativnim i emulgirajućim svojstvima. Najnovije preporuke vezane uz kozmetičku primjenu predstavljaju bakuchiol kao fitoalternativu retinolu, s potencijalno puno višom razinom sigurnosti prilikom uporabe. Ovaj spoj, poput retinola i njegovih derivata, može se naširoko koristiti u dermatologiji i njezi kože za sprječavanje nastanka bora, akni i hiperpigmentacije kože. Iako retinol i bakuchiol ne pokazuju strukturne sličnosti, imaju sličan profil ekspresije gena, posebno u nekim ključnim genima i proteinima uključenima u procese starenja kože. Kako se tržište proizvoda za prevenciju i regresiju (foto)starenja kože koji se izdaju bez recepta kontinuirano širi, želja za proizvodima sličnim retinoidima, ali s boljim profilom nuspojava, raste. Bakuchiol ima nekoliko značajnih prednosti u odnosu na retinol, uključujući izvrsnu fotokemijsku i hidrolitičku stabilnost, dobar sigurnosni profil i lakoću formuliranja zbog mogućnosti miješanja s velikim brojem emolijensa i solubilizatora. Također, bakuchiol se može koristiti u dnevnoj njezi kože zbog svoje fotostabilnosti.

Abstract (english)

Bakuchiol is a prenylated phenolic monoterpene extracted from the fruit of Cullen corylifolium L., which belongs to the plant family Fabaceae (Leguminosae). Bakuchiol is approved in the European Union as a safe component of cosmetic products. The cosmetic ingredient database of the European Commission (CosIng) recommends its use as an ingredient with antimicrobial, antioxidant and emulsifying properties. The latest recommendations related to cosmetic application present bakuchiol as a phytoalternative to retinol, with a potentially much higher level of safety when used. This compound, like retinol and its derivatives, can be widely used in dermatology and skin care to prevent wrinkles, acne and hyperpigmentation. Although retinol and bakuchiol do not show structural similarities, they have similar gene expression profiles, especially in particular key genes and proteins involved in skin aging. As the market for over-the-counter anti-aging products continues to expand, the demand for products similar to retinoids, but with a better side effect profile, is growing. Bakuchiol has several significant advantages over retinol, including excellent photochemical and hydrolytic stability, a good safety profile, and ease of formulation due to its ability to be mixed with a wide variety of emollients and solubilizers. Moreover, due to its photostability, bakuchiol can be used during the daytime.

• Keywords: bakuchiol; retinoidi; starenje kože; hiperpigmentacija
• Keywords (english): bakuchiol; retinoids; skin ageing; hyperpigmentation
• Language: croatian
• URN:NBN: urn:nbn:hr:163:786244
• Study programme: Title: Pharmacy - integrated undergraduate and graduate - university study; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: sveučilišni magistar farmacije (sveučilišni magistar farmacije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2024-06-13 10:19:56