Priprema i karakterizacija vezikularnog fosfolipidnog gela

master's thesis

• Title (english): Preparation and characterization of vesicular phospholipid gel
• Author: Maja Crnković
• Mentor: Željka Vanić (mentor)
• Committee member: Željka Vanić (predsjednik povjerenstva)
• Committee member: Zora Rukavina (član povjerenstva)
• Committee member: Lovorka Vujić (član povjerenstva)
• Granter: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of pharmaceutical technology); Zagreb
• Defense date and country: 2024-03-28, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract

Svrha ovoga rada bila je pripraviti i okarakterizirati polučvrstu formulaciju liposoma iznimno visoke
koncenteracije fosfolipida (vezikularni fosfolipidni gel, VFG). Za pripravu je korišten sojin
fosfatidilkolin i hidrofilna djelatna tvar. Primjenom visokotlačnog homogenizatora pripravljen je
VFG male veličine vezikula i relativno homogene distribucije veličina. Uklapanje hidrofilne djelatne
tvari u unutarnju vodenu fazu bilo je visoko u usporedbi s klasičnim metodama priprave liposoma.
Izmjerena teksturna svojstva VFG-a pokazuju odgovarajuću čvrstoću i razmazivost prikladnu za
dermalnu primjenu.

Abstract (english)

The aim of this study was to prepare and characterize a semi-solid formulation of liposomes with an
extremely high concentration of phospholipids, i.e., vesicular phospholipid gel (VPG). Soybean
phosphatidylcholine and a hydrophilic model drug were used for the preparation of VPG. Using a
high-pressure homogenizer, VPG with a small size of vesicles and a relatively homogeneous size
distribution was prepared. Incorporation of the hydrophilic drug into the internal aqueous phase of
VPG was high compared to classical methods of liposome preparation. Texture analysis of VPG
showed adequate hardness and spreadability suitable for dermal application.

• Keywords: vezikularni fosfolipidni gel; liposomi; visokotlačna homogenizacija; fizikalno-kemijska karakterizacija; teksturna analiza
• Keywords (english): vesicular phospholipid gel; liposomes; high pressure homogenization; physico-chemical characterization; texture analysis
• Language: croatian
• URN:NBN: urn:nbn:hr:163:728052
• Study programme: Title: Pharmacy - integrated undergraduate and graduate - university study; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: sveučilišni magistar farmacije (sveučilišni magistar farmacije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Embargoed access; Embargo expiration date: 2025-09-28
• Created on: 2024-06-13 11:50:49