Ispitivanje farmakopejskih svojstava kvalitete i antioksidativne aktivnosti tableta za žvakanje koje sadrže ekstrakt kore crvenog brijesta

master's thesis

• Title (english): Analyzing the pharmacopeial properties of the quality and antioxidant activity of chewable tablets that contain red elm bark extract
• Author: Kristian Morić-Španić
• Mentor: Ana Mornar Turk (mentor)
• Committee member: Ana Mornar Turk (predsjednik povjerenstva)
• Committee member: Daniela Amidžić Klarić (član povjerenstva)
• Committee member: Domagoj Kifer (član povjerenstva)
• Granter: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of pharmaceutical analysis); Zagreb
• Defense date and country: 2024-07-10, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract

Kora crvenog brijesta ima široko rasprostranjenu tradicionalnu upotrebu, poglavito kod gastrointestinalnih smetnji poput želučanih tegoba i dijareje te respiratornih smetnji poput kašlja. Na tržištu su prisutni pripravci koji sadrže koru brijesta u obliku dodataka prehrani. Dodaci prehrani ne podliježu istim zakonima i strogim kontrolama kao lijekovi. Cilj ovog rada bio je ispitati kvalitetu prema zahtjevima Farmakopeje Sjedinjenih Američkih Država te procijeniti antioksidativnu aktivnost dodatka prehrani koji sadrži ekstrakt kore crvenog brijesta. Rezultati ispitivanja kvalitete pokazuju da pripravak zadovoljava kriterije kvalitete Farmakopeje Sjedinjenih Američkih Država. Antioksidativna aktivnost procijenjena je DPPH metodom i pokazano je da povećanjem koncentracije ekstrakta linearno raste i antioksidativna aktivnost u ispitivanom području koncentracija.

Abstract (english)

The red elm bark has a widespread traditional use, mainly for gastrointestinal problems such as stomach disorders and diarrhea, but also for respiratory problems such as cough. Products on the market contain red elm bark in the form of dietary supplements. However, dietary supplements are not subject to the same laws and rigorous controls as medicines. This study aimed to evaluate the quality of such dietary supplement according to United States Pharmacopeia requirements and also to measure its antioxidant activity. The results of quality tests show that the supplement satisfies the United States Pharmacopeia quality criteria. The antioxidant activity was evaluated by the DPPH method, and it was shown that increasing the concentration of the extract linearly increases the antioxidant activity in the examined range of concentration.

• Keywords: farmakopejska svojstva kvalitete; antioksidativna aktivnost; crveni brijest
• Keywords (english): pharmacopeial properties of the quality; antioxidant activity; red elm
• Language: croatian
• URN:NBN: urn:nbn:hr:163:863364
• Study programme: Title: Pharmacy - integrated undergraduate and graduate - university study; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: sveučilišni magistar farmacije (sveučilišni magistar farmacije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2024-07-26 08:11:09