Utjecaj koronavirusa na crijevnu mikrobiotu

postgraduate specialist thesis

• Author: Sandra Zugan
• Mentor: Lidija Bach-Rojecky (mentor)
• Committee member: Donatella Verbanac (predsjednik povjerenstva)
• Committee member: Lidija Bach-Rojecky (član povjerenstva)
• Committee member: Blaženka Kos (član povjerenstva)
• Granter: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of pharmacology); Zagreb
• Defense date and country: 2024-07-24, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract

Cilj istraživanja: Ravnoteža crijevne mikrobiote od velike je važnosti za očuvanje zdravlja ljudi. Stanje kada je ravnoteža među komponentama mikrobiote narušena, naziva se disbioza. Godine 2019. u kineskom gradu Wuhan izbijala je bolest teškog akutnog respiratornog sindroma nazvana COVID-19, koja je uzrokovana novim koronavirusom SARS-CoV-2. Osim infekcije respiratornog sustava, SARS-CoV-2 također inficira gastrointestinalni trakt, gdje se intenzivno razmnožava. Cilj ovog rada je pružiti uvid u promjene sastava crijevne mikrobiote kod pacijenata s COVID-19 i kod osoba koje su se oporavile od COVID-19, kao i uvid u terapijske intervencije koje utječu na promjenu sastava crijevne mikrobiote u pacijenata s COVID-19.
Metode: Za izradu ovog preglednog rada pretraživana je dostupna znanstvena literatura na temu crijevne mikrobiote, COVID-19, analize crijevne mikrobiote u COVID-19 pacijenata te utjecaja probiotika i prehrane na crijevnu mikrobiotu kod COVID-19 pacijenata.
Rezultati: Sastav crijevne mikrobiote COVID-19 pacijenata te osoba koje su se oporavile od COVID-19 pokazuje značajnu disbiozu u usporedbi sa zdravim kontrolama. Dokazano je smanjenje mikrobne raznolikosti i mikrobnog bogatstva, kao i promjene u sastavu crijevne mikrobiote u obliku gubitka korisnih bakterija i povećanja brojnosti patogenih bakterija. Disbioza crijeva usko je povezana s gastrointestinalnim simptomima i težinom bolesti COVID-19.
Zaključak: Za utvrđivanje odražavaju li te promjene u sastavu crijevne mikrobiote uzrok ili posljedicu COVID-19, potrebno je provesti dodatna istraživanja. Terapijska intervencija na mikrobiotu putem probiotika, prebiotika i fekalne transplantacije je jedna od obećavajućih strategija za liječenje COVID-19 u budućnosti, ali neophodna su daljnja istraživanja

Abstract (english)

Objectives: The intestinal microbiota balance is of great importance for maintaining human health. The condition when the balance in the microbial community is disturbed is called dysbiosis. In 2019, a severe acute respiratory syndrome disease called COVID-19 broke out in the Chinese city of Wuhan. It is an infectious disease caused by the new coronavirus SARS-CoV-2. In addition to infection of the respiratory system, SARS-CoV-2 also infects the gastrointestinal tract, where it multiplies intensively. The aim of this work is to provide insight into changes in the intestinal microbiota compostion in patients with COVID-19 and in people who have recovered from COVID-19, as well as insight into therapeutic interventions that affect changes in the intestinal microbiota composition in patients with COVID-19.
Methods: The methods included a review of available scientific literature on the topic of intestinal microbiota, COVID-19, analysis of intestinal microbiota in COVID-19 patients, and the impact of probiotics and nutrition on intestinal microbiota in COVID-19 patients.
Results: The composition of the intestinal microbiota of COVID-19 patients and persons who have recovered from COVID-19 shows significant dysbiosis compared to healthy controls. A decrease in microbial diversity and richness, as well as changes in the composition of the intestinal microbiota in the form of a loss of beneficial bacteria and an increase in the number of pathogenic bacteria, have been proven. Gut dysbiosis is closely related to gastrointestinal symptoms and the severity of the disease of COVID-19.
Conclusion: To determine whether these changes in the composition of the intestinal microbiota reflect the cause or effect of COVID-19, it is necessary to perform additional research. Therapeutic intervention on the microbiota through probiotics, prebiotics and fecal transplantation is one of the promising strategies for the treatment of COVID-19 in the future, but further research is necessary.

• Keywords: koronavirus; SARS-CoV-2; COVID-19; crijevna mikrobiota; disbioza crijeva
• Keywords (english): coronavirus; SARS-CoV-2; COVID-19; intestinal microbiota; intestinal dysbiosis
• Language: croatian
• URN:NBN: urn:nbn:hr:163:211165
• Study programme: Title: Phytopharmacy with dietotherapy - specialistic study - university study; Study programme type: university; Study level: postgraduate specialist; Academic / professional title: sveučilišni specijalist fitofarmacije s dijetoterapijom (sveučilišni specijalist fitofarmacije s dijetoterapijom)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2024-10-07 10:37:40