COVID 19 – današnje mogućnosti liječenja

postgraduate specialist thesis

• Author: Ivona Šaker
• Mentor: Iveta Merćep https://orcid.org/0000-0003-2824-9222 (mentor)
• Committee member: Maja Ortner Hadžiabdić (predsjednik povjerenstva)
• Committee member: Iveta Merćep https://orcid.org/0000-0003-2824-9222 (član povjerenstva)
• Granter: University of Zagreb; Faculty of Pharmacy and Biochemistry; Zagreb
• Defense date and country: 2024-06-12, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract

Cilj istraživanja: Cilj ovog rada je pregledno prikazati današnje terapijske mogućnosti u prevenciji i liječenju bolesti COVID-19 i značajne znanstvene spoznaje vezano za njihovu djelotvornost i sigurnost.
Materijali i metode: U tu svrhu korištena je trenutno dostupna stručna i znanstvena literatura te publikacije baza lijekova Europske agencije za lijekove i Agencije za lijekove i medicinske proizvode u Hrvatskoj te drugi raspoloživi izvori u razdoblju od pojave pandemije 2019. do rujna 2023.
Rezultati: Pregledno su prikazani cjepiva (mRNA, proteinska, vektorska ili inaktivirana cjepiva) i lijekovi (antivirusna monoklonska protutijela, oralni antivirusni lijekovi, imunomodulatori, antivirotici za sistemsku primjenu) koji su trenutno odobreni za prevenciju i liječenje COVID-19 bolesti.
Zaključak: Zahvaljujući iznimnim naporima stručne i znanstvene javnosti od proglašenja pandemije COVID-19 u ožujku 2020., danas postoje učinkovita cjepiva i lijekovi protiv bolesti COVID-19 s prihvatljivim sigurnosnim profilom.
Cjepiva protiv bolesti COVID-19 su prošla kroz opsežna klinička ispitivanja koja su uključivala desetke tisuća ispitanika kako bi se osigurala njihova sigurnost i učinkovitost. Na temelju tih podataka dobili su regulatorno odobrenje za stavljanje u promet.
Kontinuiranim istraživanjem i razvojem cjepiva, danas postoje i prilagođena cjepiva koja pružaju bolju zaštitu protiv prevladavajućih varijanti virusa SARS-CoV-2.
Dok su COVID-19 cjepiva primarno dizajnirana za prevenciju bolesti COVID-19, danas su dostupni lijekovi koji se mogu koristiti za liječenje već zaraženih pojedinaca virusom SARS-CoV-2 i tako doprinositi u kontroli i smanjenju napredovanja bolesti odmah nakon njihove primjene.
Budući da je situacija s bolesti COVID-19 dinamična, ključno je pratiti najnovije smjernice i preporuke zdravstvenih regulatornih tijela i stručnjaka o najnovijim informacijama o liječenju i prevenciji bolesti COVID-19.

Abstract (english)

Objectives: The goal of this thesis is to present an overview of today's therapeutic possibilities in the prevention and treatment of COVID-19 and significant scientific knowledge related to their efficacy and safety.
Materials and methods: For this purpose, currently available professional and scientific literature, including publications of the European Medicines Agency and the Agency for Medicinal Products and Medical Devices of Croatia drug database and other available sources were examined in the period from the pandemic onset in 2019 until September 2023.
Results: Vaccines (mRNA, protein, vector or inactivated vaccines) and medicinal products (antiviral monoclonal antibodies, oral antiviral medicinal products, immunomodulators, antivirals for systemic use) that are currently approved for the prevention and treatment of COVID-19 disease are presented in one place.
Conclusion: Due to the exceptional efforts of the professional and scientific public from the declaration of the COVID-19 pandemic in March 2020, today there are effective vaccines and medicinal products against COVID-19 disease with an acceptable safety profile.
COVID-19 vaccines have gone through extensive clinical trials involving tens of thousands of participants to ensure their safety and efficacy. Based on these data, they received regulatory approval for their placement on the market.
Due to continuous vaccine research and development, there are now adapted vaccines that provide better protection against the prevailing variants of the SARS-CoV-2 virus.
While the COVID-19 vaccines are primarily designed for the prevention of COVID-19 disease, today's available medicinal products can be used to treat individuals already infected with the SARS-CoV-2 virus and thus contribute to controlling and reducing the progression of the disease immediately after their administration.
Since the situation with the COVID-19 disease is dynamic, it is crucial to follow the latest guidelines and recommendations from health authorities and experts regarding the latest information on COVID-19 treatment and prevention.

• Keywords: COVID-19; SARS-CoV-2; farmakoterapija; cjepiva
• Keywords (english): COVID-19; SARS-CoV-2; pharmacotherapy; vaccines
• Language: croatian
• URN:NBN: urn:nbn:hr:163:476226
• Study programme: Title: Clinical pharmacy - specialistic study - university study; Study programme type: university; Study level: postgraduate specialist; Academic / professional title: sveučilišni specijalist kliničke farmacije (sveučilišni specijalist kliničke farmacije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2024-10-07 11:05:49