Farmakološke mogućnosti liječenja poremećaja prehrane

master's thesis

• Title (english): Pharmacological treatment options for eating disorders
• Author: Sandra Šumak
• Mentor: Lidija Bach-Rojecky (mentor)
• Committee member: Lidija Bach-Rojecky (predsjednik povjerenstva)
• Committee member: Petra Turčić (član povjerenstva)
• Committee member: Miranda Sertić (član povjerenstva)
• Granter: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of pharmacology); Zagreb
• Defense date and country: 2024-11-30, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract

Poremećaji prehrane su kompleksne psihijatrijske bolesti s visokim stopama mortaliteta i morbiditeta.
Karakteriziraju ih abnormalne prehrambene navike i ponašanja, što posljedično ugrožava fizičko
zdravlje i psihosocijalno funkcioniranje oboljelih. Osobe koje pate od ovih poremećaja često imaju
iskrivljenu percepciju vlastitog tijela i tjelesne težine. Iako etiologija poremećaja prehrane nije u
potpunosti razjašnjena, smatra se da su njihovi uzroci složeni i da uključuju biološke, psihološke i
socijalne čimbenike. Liječenje ovih poremećaja zahtijeva sveobuhvatan i multidisciplinaran pristup. U
odraslih pacijenata, trenutna se terapija fokusira na različite bihevioralno orijentirane psihoterapije koje
imaju za cilj poboljšanje simptoma i postizanje zdrave tjelesne težine. Psihoterapija ostaje ključni dio
tretmana, no farmakoterapija predstavlja značajnu alternativu za pacijente koji ne pokazuju dovoljno
napretka s psihoterapijskim metodama. Psihoaktivni lijekovi, iako nemaju primarnu ulogu u liječenju
poremećaja prehrane, značajno doprinose kliničkoj praksi, osobito kod pacijenata s teškim
simptomima. Trenutno su odobreni antidepresiv fluoksetin za bulimiju nervozu i psihostimulans
lisdeksamfetamin za poremećaj prejedanja. Unatoč određenim ograničenjima u studijama provedenima
tijekom posljednjih nekoliko desetljeća, istraživanja u području farmakoterapije kod ovih poremećaja
pokazala su značajan napredak. U budućnosti, fokus će biti usmjeren na nove farmakološke mogućnosti
te biološki utemeljene tretmane, kako bi se dodatno unaprijedila učinkovitost liječenja.

Abstract (english)

Eating disorders are complex psychiatric illnesses with high rates of mortality and morbidity. They are
characterized by abnormal eating habits and behaviors, which consequently jeopardize the physical
health and psychosocial functioning of those affected. Individuals suffering from these disorders often
have a distorted perception of their own body and weight. Although the etiology of eating disorders is
not fully understood, it is believed that their causes are complex and involve biological, psychological,
and social factors. Treatment of these disorders requires a comprehensive and multidisciplinary
approach. In adult patients, current therapy focuses on various behavioral-oriented psychotherapies
aimed at improving symptoms and achieving a healthy body weight.Psychotherapy remains a key
component of treatment, while pharmacotherapy represents a significant alternative for patients who do
not show sufficient progress with psychotherapeutic methods. Psychoactive medications, although not
primary used in the treatment of eating disorders, significantly contribute to clinical practice, especially
in patients with severe symptoms. Currently, the antidepressant fluoxetine is approved for bulimia
nervosa, and the psychostimulant lisdexamfetamine is approved for binge eating disorder. Despite
certain limitations in studies conducted over the past few decades, research in the field of
pharmacotherapy for these disorders has shown significant progress. In the future, the focus will be
directed toward new pharmacological options and biologically based treatments to further enhance the
effectiveness of treatment.

• Keywords: poremećaji prehrane; farmakoterapija poremećaja prehrane; regulacija apetita; psihoterapija
• Keywords (english): eating disorders; pharmacotherapy of eating disorders; appetite regulation; psychotherapy
• Language: croatian
• URN:NBN: urn:nbn:hr:163:232470
• Study programme: Title: Pharmacy - integrated undergraduate and graduate - university study; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: sveučilišni magistar farmacije (sveučilišni magistar farmacije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2025-01-29 12:16:14