Utjecaj usluge upravljanja farmakoterapijom na lipidogram u pacijenata starije životne dobi u Domu zdravlja Zagreb Centar

master's thesis

• Title (english): The impact of comprehensive medication management services on the lipid profile in elderly patients at the Zagreb-Center Health Center
• Author: Lorena Jozić
• Mentor: Andrea Brajković (mentor)
• Committee member: Andrea Brajković (predsjednik povjerenstva)
• Committee member: Iva Mucalo (član povjerenstva)
• Committee member: Kristina Radić (član povjerenstva)
• Granter: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Centre for applied pharmacy); Zagreb
• Defense date and country: 2024-11-14, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract

Cilj ovog istraživanja bio je procijeniti utjecaj usluge upravljanja farmakoterapijom (CMM) na
lipidogram kod starijih pacijenata koji koriste statine u terapiji u Domu zdravlja Zagreb Centar,
opisati predložene intervencije za rješavanje terapijskih problema povezanih sa statinima te stupanj
njihove prihvaćenosti, kao i procijeniti učinak CMM usluge na postizanje terapijskih ciljeva u
liječenju hiperlipidemije, hipertenzije i šećerne bolesti tipa 2, najčešćih komorbiditeta povezanih s
hiperlipidemijom. Provedeno je prospektivno intervencijsko istraživanje u trajanju od šest godina.
U istraživanju je sudjelovalo 128 pacijenata prosječne starosti 74 godina i većinom ženskog spola.
Najčešće intervencije koje su provedene radi rješavanja terapijskih problema vezanih uz statine
uključivale su uvođenje nove terapije, povećanje doze lijeka, promjenu lijeka i kontrolu
laboratorijskih nalaza. Istraživanje je pokazalo statistički značajan pad LDL kolesterola i ukupnog
kolesterola kod starijih pacijenata. Rezultati su pokazali da CMM usluga doprinosi postizanju
terapijskih ciljeva i optimizaciji liječenja hiperlipidemije te boljoj kontroli komorbiditeta kod
starijih pacijenata, što ukazuje na potrebu širenja ove usluge u druge domove zdravlja radi
unaprjeđenja zdravstvene skrbi za stariju populaciju.

Abstract (english)

The objective of this study was to assess the impact of Comprehensive Medication Management
(CMM) services on the lipid profile of elderly patients on statin therapy at the Zagreb-Center Health
Center, to describe proposed interventions aimed at resolving drug therapy problems (DTP) with
statins and their acceptance rates, and to evaluate the effectiveness of CMM in achieving therapeutic
goals for managing hyperlipidemia, hypertension, and type 2 diabetes—the most common
comorbidities associated with hyperlipidemia. This six-year prospective interventional study
included 128 patients, with an average age of 74 years, the majority of whom were female. The most
frequently proposed interventions to address DTP with statins included initiating new therapy,
increasing drug doses, switching medications, and monitoring laboratory results. Most interventions
involved atorvastatin and rosuvastatin, the statins most commonly used in therapy and those required
the most adjustments. The results showed that CMM services contribute to achieving therapeutic
goals, optimizing hyperlipidemia treatment, and improving control of comorbidities in elderly
patients. These findings highlight the need to expand CMM services to other health centers to
improve healthcare for the elderly population.

• Keywords: usluga upravljanja farmakoterapijom; kardiovaskularni rizik; stariji pacijenti; optimizacija terapije; lipidni profil
• Keywords (english): comprehensive medication management services; cardiovascular risk; elderly patients; therapy optimization; lipid profile
• Language: croatian
• URN:NBN: urn:nbn:hr:163:711340
• Study programme: Title: Pharmacy - integrated undergraduate and graduate - university study; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: sveučilišni magistar farmacije (sveučilišni magistar farmacije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2025-01-29 13:50:10