| Abstract | Cilj istraživanja: Utvrditi i definirati najčešće terapijske probleme u pacijenata s barem jednim lijekom iz skupine
benzodiazepina i z-lijekova na razini primarne zdravstvene zaštite u Republici Hrvatskoj.
Materijali i metode: Provedeno je prospektivno, intervencijsko istraživanje u FTS unutar DZZC gdje se provodila usluga
upravljanja farmakoterapijom u razdoblju od siječnja 2018. do travnja 2024. Prikupljeni su sociodemografski i antropometrijski
podatci o pacijentu, njegovim bolestima i lijekovima te su identificirani terapijski problemi i izrađen je plan skrbi s predloženim
intervencijama. Kriterij za izbor sudionika bio je ustanovljen terapijski problem povezan s primjenom benzodiazepina ili z-lijeka.
Podatci su analizirani metodom deskriptivne statistike pomoću Microsoft Excel programa.
Rezultati: U istraživanje je bilo uključeno 118 pacijenata, od kojih su 77,1 % bile žene, prosječne dobi 71,2 ± 11 godina.
Prosječno su pacijenti imali 10,2±6,0 komorbiditeta i 11,2±5,1 lijekova. Identificirano je ukupno 1042 terapijskih problema
(8,83±3,0 po pacijentu), od čega se 14,5 % odnosilo na benzodiazepine i z-lijekove (prosječno 1,28 po pacijentu). Najčešći
terapijski problemi bili su previsoka doza (53,2 % za benzodiazepine, 55,6 % za z-lijekove), nepotrebna terapija (23,4 % i 11,1
%) te nuspojava lijeka (13,7 % i 14,8 %). Najčešće predložena intervencija bila je prekid terapije (45 % za benzodiazepine i 40,7
% za z-lijekove). Ukupno je 52,4 % terapijskih problema povezanih s primjenom benzodiazepina i 37,0 % povezanih s primjenom z-lijekova bilo riješeno.
Zaključak: Rezultati ovog istraživanja pokazuju da ukoliko farmaceut u radu koristi jasno definiran i standardiziran proces rada
ljekarničke prakse, u suradnji sa liječnicima obiteljske medicine i pacijentima, može riješiti velik broj terapijskih problema
povezanih s neracionalnom primjenom benzodiazepina i z- lijekova. |
| Abstract (english) | Objective: To identify and define the most common drug therapy problems in patients using at least one drug from the
benzodiazepine and z-drug groups at the primary healthcare level in the Republic of Croatia.
Materials and Methods: A prospective, interventional study was conducted within the FTS at the DZZC, where a
comprehensive medication management service was provided from January 2018 to April 2024. Sociodemographic and
anthropometric data about the patients, their diseases, and medications were collected, and drug therapy problems were identified.
A care plan with proposed interventions was developed. The inclusion criterion for participants was the presence of a drug
therapy problem related to the use of benzodiazepines or z-drugs. The data were analyzed using descriptive statistics with
Microsoft Excel.
Results: A total of 118 patients were included in the study, of which 77.1% were women, with an average age of 71.2 ± 11 years. On average, patients had 10.2 ± 6.0 comorbidities and 11.2 ± 5.1 medications. A total of 1042 drug therapy problems were identified (8.83 ± 3.0 per patient), of which 14.5% were related to benzodiazepines and z-drugs (an average of 1.28 per patient). The most common drug therapy problems were excessive dosage (53.2% for benzodiazepines, 55.6% for z-drugs), unnecessary therapy (23.4% and 11.1%), and drug side effects (13.7% and 14.8%). The most frequently proposed intervention was discontinuing the therapy (45% for benzodiazepines and 40.7% for z-drugs). In total, 52.4% of drug therapy problems related to the use of benzodiazepines and 37.0% related to z-drugs were resolved.
Conclusion: The results of this study show that when a pharmacist employs a clearly defined and standardized working process in pharmacy practice, in collaboration with family medicine doctors and patients, a large number of drug therapy problems related to the irrational use of benzodiazepines and z-drugs can be resolved. |
