Klinička primjena bakteriofaga

master's thesis

• Title (english): Clinical use of bacteriophages
• Author: Josipa Đuzel
• Mentor: Maja Šegvić Klarić (mentor)
• Committee member: Maja Šegvić Klarić (predsjednik povjerenstva)
• Committee member: Darija Stupin Polančec (član povjerenstva)
• Committee member: Maja Friščić (član povjerenstva)
• Granter: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of microbiology); Zagreb
• Defense date and country: 2024-11-15, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract

Terapija bakteriofagom, koja koristi viruse za liječenje bakterijskih infekcija, ima dugu povijest, ali je izgubila popularnost s
razvojem antibiotika. S obzirom na krizu otpornosti na antimikrobne lijekove, ponovno je zainteresirala mnoge zemlje. Dok je
Zapadni svijet tek nedavno počeo istraživati ovu terapiju, u Istočnoj Europi se ona već duže vrijeme prakticira. Cilj ovog
diplomskog rada bio je pružiti pregled slučajeva rezistentnih bakterijskih infekcija tretiranih terapijom... More bakteriofaga. Posebna
pažnja posvećena je grupiranju najčešćih vrsta infekcija kako bi se razumjeli obrasci i trendovi u primjeni. Rad također detaljno
opisuje kliničke profile pacijenata, uključujući demografske podatke, povijest bolesti i karakteristike infekcija. Analiziran je
način primjene terapije, uključujući doziranje i trajanje liječenja, te moguće kombinacije s drugim pristupima. Na kraju,
provedena je evaluacija uspješnosti terapije, uzimajući u obzir ishode liječenja i nuspojave, kako bi se procijenila učinkovitost
ovog pristupa u borbi protiv otpornijih bakterijskih infekcija. Ovaj diplomski rad ukazuje na to da bakteriofagi predstavljaju
obećavajuću alternativu za liječenje rezistentnih bakterijskih infekcija, nudeći inovativan pristup u borbi protiv otpornosti na
antibiotike. Također, u ovom radu naglašavamo veliku potrebu za uspostavljanjem jasno definirane regulative i smjernica za
primjenu terapije bakteriofagima, kako bi se osigurala dosljednost i relevantnost dobivenih podataka. Less

Abstract (english)

Phage therapy, which uses viruses to treat bacterial infections, has a long history but lost popularity with the development of
antibiotics. However, the current crisis of antimicrobial resistance has reignited interest in this therapy in many countries.
Although the Western world has only recently begun exploring this therapy, it has been practiced for a longer time in Eastern
Europe. The aim of this thesis was to provide an overview of cases of resistant bacterial infections... More treated with phage therapy.
Special attention was given to categorizing the most common types of infections to understand patterns and trends in
application. The paper also details the clinical profiles of patients, including demographic data, medical history, and
characteristics of infections. The method of therapy application was analyzed, including dosage, duration of treatment, and
potential combinations with other approaches. Finally, an evaluation of the therapy's success was conducted, considering
treatment outcomes and side effects to assess the effectiveness of this approach in combating resistant bacterial infections. This
thesis highlights that phages represent a promising alternative for treating resistant bacterial infections, offering an innovative
approach in the fight against antibiotic resistance. Additionally, we emphasize the urgent need for establishing clearly defined
regulations and guidelines for the application of phage therapy to ensure the consistency and relevance of the obtained data. Less

• Keywords: bakteriofag; fag; bakterija; infekcija
• Keywords (english): bacteriophage; phage; bacteria; infection
• Language: croatian
• URN:NBN: urn:nbn:hr:163:131275
• Study programme: Title: Pharmacy - integrated undergraduate and graduate - university study; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: sveučilišni magistar farmacije (sveučilišni magistar farmacije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2025-02-05 14:02:33