Antimigrenski učinak običnog lopuha – Petasites hybridus (L.) P. Gaertn., B. Mey. et Schreb.

postgraduate specialist thesis

• Author: Marlena Kovačević
• Mentor: Sanda Vladimir-Knežević (mentor)
• Committee member: Biljana Blažeković (predsjednik povjerenstva)
• Committee member: Sanda Vladimir-Knežević (član povjerenstva)
• Committee member: Maja Lusina Kregar (član povjerenstva)
• Granter: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of pharmacognosy); Zagreb
• Defense date and country: 2024-09-27, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract

Cilj istraživanja
Cilj je ovog specijalističkog rada pružiti sveobuhvatan pregled znanstvenih spoznaja o
antimigrenskom učinku običnog lopuha – Petasites hybridus (L.) P. Gaertn., B. Mey. et Schreb
kako bi se prema znanstveno utemeljenim dokazima mogli donijeti relevantni zaključci o
njihovu biomedicinskom potencijalu.
Materijali
Istraživanje u ovom radu teorijskog je karaktera i uključuje detaljan pregled dostupnih stručnih
i znanstvenih podataka o toj temi. Pretražene su relevantne bibliografske baze podataka kao što
su PubMed, Scopus, ScienceDirect i Cochrane. Prikupljeni podaci uključivali su klinička
ispitivanja koja su zatim sustavno prezentirana.
Rezultati
Migrena je kronična bolest koja pogađa 12 % svjetske populacije, a svrstava se među najčešće
neurološke bolesti. Unatoč terapijskim mogućnostima i novim znanstvenim spoznajama o
patogenezi te bolesti, još uvijek nisu postignuti zadovoljavajući ishodi liječenja migrene. Velika
je potreba za preventivnim liječenjem migrene, kako bi se smanjila učestalost napadaja i
spriječilo napredovanje bolesti – što uključuje i tradicionalnu primjenu prirodnih ljekovitih
tvari. Učinkovitost običnog lopuha u sprječavanju glavobolja i migrena proizlazi iz njegova
protuupalnog i spazmolitičnog učinka. Klinički je ispitan jedino ekstrakt običnog lopuha
Petadolex® iz kojeg su uklonjene toksične alkaloidne sastavnice. Rezultati ukazuju na veliki
potencijal ekstrakta u profilaksi migrene u djece i odraslih, uz sigurnu primjenu u dnevnoj dozi
50 – 150 mg.
Zaključak
Iako je razina kliničkih dokaza o djelovanju običnog lopuha nedostatna, tradicionalna primjena
i dosadašnje znanstvene spoznaje ukazuju na njegov veliki potencijal i ohrabruju daljnja
klinička istraživanja.

Abstract (english)

Objectives
The aim of this study is to provide a comprehensive overview of scientific knowledge on the
effects of the antimigrenic effect of butterbur - Petasites hybridus (L.) P. Gaertn., B. Mey. et
Schreb. in order to draw relevant conclusions about their potential for therapeutic application.
Materials and methods
The research in this work is theoretical and involves a detailed review of the available
professional and scientific data on the subject. Relevant bibliographic databases such as
PubMed, Scopus, ScienceDirect and Cochrane were searched. The collected data included
clinical trials, which were then systematically presented.
Results
Migraine is a chronic disease that affects 12 % of the world's population as one of the most
common neurological disorders. Despite the therapeutic possibilities and new scientific
knowledge about the pathogenesis of this disease, no satisfactory results have yet been achieved
in the treatment of migraine. There is a great need for preventive migraine treatment to reduce
the frequency of attacks and prevent the progression of the disease, including the traditional use
of natural products. Butterbur's effectiveness in preventing headaches and migraines is due to
its anti-inflammatory and antispasmodic effects. Petadolex® butterbur extract, from which the
toxic alkaloid components have been removed, is the only one that has been clinically tested.
The clinical studies carried out indicate great potential in the prophylaxis of migraine in children
and adults, with a daily dose of 50 – 150 mg being safe.
Conclusion
Although the clinical evidence for the effects of butterbur is insufficient, traditional use and
current scientific findings point to its great potential and encourage further clinical research.

• Keywords: migrena; antimigrenski učinak; obični lopuh; Petasites hybridus
• Keywords (english): migraine; antimigraine effect; butterbur; Petasites hybridus
• Language: croatian
• URN:NBN: urn:nbn:hr:163:265148
• Study programme: Title: Phytopharmacy with dietotherapy - specialistic study - university study; Study programme type: university; Study level: postgraduate specialist; Academic / professional title: sveučilišni specijalist fitofarmacije s dijetoterapijom (sveučilišni specijalist fitofarmacije s dijetoterapijom)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2025-02-07 10:47:39