Učinak kemferola na zacjeljivanje rana

postgraduate specialist thesis

• Author: Ivana Grigić Škrlec
• Mentor: Marijana Zovko Končić (mentor)
• Committee member: Marijana Zovko Končić (predsjednik povjerenstva)
• Committee member: Anita Hafner (član povjerenstva)
• Committee member: Zdenka Kalođera (član povjerenstva)
• Granter: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of pharmacognosy); Zagreb
• Defense date and country: 2024-11-28, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract

Cilj istraživanja
Na tržištu raste interes za pripravcima biljnog porijekla za liječenje različitih oboljenja,
uključujući i dermatološke probleme. Kemferol je dobro poznati flavonoid prisutan u brojnim
biljnim vrstama koje se tradicionalno koriste u cijeljenju rana. Cilj ovog rada bio je napraviti
pregled istraživanja kemferola kao aktivne biljne sastavnice ekstrakata koji se primjenjuju kao
pomoć u cijeljenju rana te istražiti njihove mehanizme djelovanja i potencijalnu učinkovitost.
Materijal i metode
U izradi specijalističkog rada korištena je elektronička baza podataka PubMed. Radom
su obuhvaćene znanstvene studije koje su ispitivale učinak kemferola i njegovih derivata na
cijeljenje rana, uključujući i učinak ekstrakata biljnih vrsta koji ih sadržavaju. U pretraživanju
su korištene ključne riječi: zacjeljivanje rana (engl. wound healing) i kemferol. Pretragom baze
PubMed 3. srpnja 2024. godine dobivena su 94 rada od kojih je 45 odgovaralo temi rada.
Rezultati
Kemferol i biljni ekstrakti koji ga sadrže pospješili su cijeljenje rana i smanjili stvaranje
ožiljaka. Učinak kemferola temeljio se na regulaciji upalnih čimbenika, pojačanoj migraciji
stanica, inhibiciji metaloproteinaza i povećanoj sintezi kolagena. Usporedbe sa standardnom
terapijom pokazale su da biljni ekstrakti s kemferolom djeluju jednako dobro ili bolje od
konvencionalnih terapija poput Madecassol®-a, fusidatne kiseline, indometacina ili
hidrokortizona. Također pokazuju bakteriostatski učinak na mikroorganizme poput Bacillus
cereus i Staphylococcus vrste, te antifungalni učinak na Candida vrste. Inovativne obloge za
rane s kemferolom i biljnim ekstraktima pokazale su dobru biokompatibilnost, povećale su
proliferaciju fibroblasta, te pokazale protuupalni i antioksidacijski učinak. Ispitani pripravci
pokazali su i značajnu učinkovitost u zacjeljivanju dijabetičkih rana. S obzirom na to da biljni
ekstrakti sadržavaju brojne sastavnice, opaženi učinak je vjerojatno posljedica sinergizma
među sastavnicama. No studije provedene s čistim kemferolom ukazuju na važnu ulogu koju
taj flavonoid ima u ukupnom učinku ispitanih ekstrakata.
Zaključak
Kemferol i biljni ekstrakti koji ga sadrže pozitivno su utjecali na cijeljenje rana u
provedenim studijama. Unatoč tome, potrebna su daljnja istraživanja kako bi se dobio bolji
uvid u učinkovitost, mehanizam djelovanja i sigurnost primjene.

Abstract (english)

Objectives
There is an increasing interest in preparations of plant origin in the market. Kaempferol
is a well-known flavonoid present in plants traditionally used in wound healing. The aim of
this work was to review the research on the topic of kaempferol and the plants containing it,
and to investigate their mechanisms of action and potential efficacy in wound healing.
Material and Methods
In the research, the electronic database PubMed was utilized. The work included
scientific studies that examined the effect of kaempferol on wound healing including the effects
of the plant extracts containing this flavonoid or its derivatives. The keywords used in the
search were: wound healing, kaempferol. The PubMed database search on 3th of July 2024
resulted in 94 papers, out of which 45 met the selected criteria.
Results
Kaempferol and plant extracts containing it promoted wound healing and reduced scar
formation. The effect of kaempferol was based on the regulation of inflammatory factors,
enhanced cell migration, inhibition of metalloproteinases, and increased collagen synthesis.
Comparisons with standard therapy indicated that the investigated samples performed equally
or better than the conventional treatments such as Madecassol®, fusidic acid, indomethacin or
hydrocortisone. They also exhibited bacteriostatic effects against microorganisms such as
Bacillus cereus and Staphylococcus species, as well as antifungal effects against Candida
species. Innovative wound dressings containing kaempferol and plant extracts demonstrated
good biocompatibility, increased fibroblast proliferation, reduced inflammation, and displayed
antioxidant effects. The investigated samples also showed significant efficacy in healing
diabetic wounds. Given that plant extracts contain numerous constituents, the observed effect
is probably due to the synergism between the extracts' components. However, studies
conducted with pure kaempferol indicate the important role that this flavonoid plays in the
overall effect of the tested extracts.
Conclusions
Kaempferol and plant extracts containing it improved wound healing in the performed
studies. Despite this, further research is needed to gain a better understanding of their efficacy,
mechanism of action and safety of use.

• Keywords: kemferol; zacjeljivanje rana
• Keywords (english): kaempferol; wound-healing
• Language: croatian
• URN:NBN: urn:nbn:hr:163:070304
• Study programme: Title: Dermatopharmacy and cosmetology - specialistic - university; Study programme type: university; Study level: postgraduate specialist; Academic / professional title: sveučilišni specijalist dermatofarmacije i kozmetologije (sveučilišni specijalist dermatofarmacije i kozmetologije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2025-02-07 12:57:40