Biljne droge za ublažavanje nesanice

postgraduate specialist thesis

• Author: Daria Šurić
• Mentor: Maja Bival Štefan (mentor)
• Committee member: Sanda Vladimir-Knežević (predsjednik povjerenstva)
• Committee member: Maja Bival Štefan (član povjerenstva)
• Committee member: Renata Jurišić Grubešić (član povjerenstva)
• Granter: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of pharmacognosy); Zagreb
• Defense date and country: 2024-09-27, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract

Cilj istraživanja
Cilj ovog specijalističkog rada je sveobuhvatan pregled dostupne znanstvene i stručne literature
o biljnim drogama koje se primjenjuju za ublažavanje nesanice. Svrha je stjecanje znanja o
njihovim učincima i mehanizmima djelovanja kod osoba s nesanicom.
Materijali i metode
Istraživanje u okviru ovog rada je teorijskog karaktera i uključuje pregled dostupne znanstvene i
stručne literature o kliničkim kao i nekliničkim istraživanjima vezanim uz predloženu temu. U
pretraživanju su korištene dostupne bibliografske baze podataka Web of Science, PubMed
(Medline), Scopus, Science Direct i Cochrane Library.
Rezultati
Biljni pripravci imaju značajnu ulogu u ublažavanju nesanice. Znanstvena literatura potvrđuje da
biljne vrste poput odoljena (Valeriana officinalis L.), matičnjaka (Melissa officinalis L.), šafrana
(Crocus sativus L.) i ašvagande (Withania somnifera (L.) Dunal) imaju značajan pozitivan učinak
u ublažavanju simptoma nesanice. Kliničke studije rađene na odoljenu pokazuju poboljšanje
kvalitete sna, posebno kod osoba s anksioznošću i nesanicom. Kliničke studije pripravaka
matičnjaka potvrđuju njegovu učinkovitost u smanjenju anksioznosti i poboljšanju kvalitete sna.
Klinička ispitivanja pripravaka koje sadrže ašvagandu ili šafran pokazuju obećavajuće rezultate,
ali su potrebna daljnja ispitivanja za potvrdu optimalnih doza i potencijalnih nuspojava.
Zaključak
Ovi rezultati ukazuju da biljni pripravci mogu poboljšati kvalitetu sna i pomoći osobama s
nesanicom. No, potrebno je više istraživanja kako bi se potvrdila njihova sigurnost i učinkovitost.
Dostatni klinički dokazi omogućili bi opsežnije uvođenje biljnih pripravaka u terapiju nesanice,
čime bi se posljedično smanjila upotreba sintetskih lijekova koji dugoročnim uzimanjem pokazuju
negativne učinke na zdravlje i kvalitetu života.

Abstract (english)

Objectives
This research aims to provide a comprehensive review of the available scientific and professional
literature on herbal drugs most used to alleviate insomnia. The purpose is to learn about their
effects and mechanisms of action in individuals with insomnia.
Materials and methods
The research in this paper is theoretical and includes a review of the available scientific and
professional literature on both clinical and non-clinical studies related to the proposed topic. The
search utilized available bibliographic databases such as Web of Science, PubMed (Medline),
Scopus, Science Direct, and Cochrane Library.
Results
Herbal preparations play a significant role in alleviating insomnia. Scientific literature confirms that
plant species such as valerian (Valeriana officinalis L.), lemon balm (Melissa officinalis L.), saffron
(Crocus sativus L.), and ashwagandha (Withania somnifera (L.) Dunal) have a notable positive
effect on reducing insomnia symptoms. Clinical studies on valerian show an improvement in sleep
quality, especially in individuals with anxiety and insomnia. Clinical studies of lemon balm
preparations confirm its effectiveness in reducing anxiety and improving sleep quality. Clinical
trials of preparations containing ashwagandha or saffron show promising results, but further
research is needed to confirm optimal doses and potential side effects.
Conclusion
These results suggest that herbal drugs can be beneficial for improving sleep quality and
supporting individuals with insomnia. However, more research is needed to confirm their safety
and efficacy. This could contribute to directing insomnia therapy towards herbal preparations,
thereby reducing the use of synthetic drugs, which have shown negative effects on health and
quality of life when used long-term.

• Keywords: biljne droge; nesanica; odoljen; matičnjak; šafran; ašvaganda; Valeriana officinalis L.; Melissa officinalis L.; Crocus sativus L.; Withania somnifera (L.) Dunal
• Keywords (english): herbal drugs; insomnia; valerian; lemon balm; saffron; ashwagandha; Valeriana officinalis L.; Melissa officinalis L.; Crocus sativus L.; Withania somnifera (L.) Dunal
• Language: croatian
• URN:NBN: urn:nbn:hr:163:880636
• Study programme: Title: Phytopharmacy with dietotherapy - specialistic study - university study; Study programme type: university; Study level: postgraduate specialist; Academic / professional title: sveučilišni specijalist fitofarmacije s dijetoterapijom (sveučilišni specijalist fitofarmacije s dijetoterapijom)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2025-03-26 09:45:05