Ekstra djevičansko maslinovo ulje i biokemijski biljezi ateroskleroze u bolesnika na antiretrovirusnoj terapiji

doctoral thesis

• Title (english): Extra virgin olive oil and atherosclerosis biomarkers in patients on antiretroviral therapy
• Author: Sanja Kozić Dokmanović; MBZ: 260183
• Mentor: Josip Begovac (mentor); MBZ: 143475
• Mentor: Nada Vrkić (komentor)
• Committee member: Jozsef Petrik (predsjednik povjerenstva)
• Committee member: Renata Zrinski Topić (član povjerenstva); MBZ: 188343
• Committee member: Željan Maleš (član povjerenstva)
• Committee member: Josip Begovac (član povjerenstva); MBZ: 143475
• Committee member: Nada Vrkić (član povjerenstva)
• Granter: University of Zagreb; Faculty of Pharmacy and Biochemistry; Zagreb
• Defense date and country: 2012-02-10, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Medical Biochemistry
• Universal decimal classification (UDC): 615 - Pharmacology. Therapeutics. Toxicology

Abstract

Bolesnici zaraženi HIV-om skloni su ranoj pojavi ateroskleroze zbog upale uzrokovane samim virusom, kao i
zbog nuspojava antiretrovirusnog liječenja. Antiaterogeno djelovanje ekstra djevičanskog maslinovog ulja
(EVOO) moglo bi umanjiti rizik od kardiovaskularnih bolesti u osoba zaraženih HIV-om. 39 HIV-om zaraženih
muških ispitanika uključeno je u križni klinički pokus. Ispitanici su konzumirali EVOO i rafinirano maslinovo
ulje (ROO) - placebo. Više od 50% ispitanika imalo je izražene čimbenike za aterosklerozu, a više od 90%
ispitanika imalo je povećanu koncentraciju malondialdehida i povećanu katalitičku koncentraciju superoksid
dismutaze. Udio rizičnih čimbenika znatno je veći u ispitanika koji se liječe inhibitorima proteaze ili
abakavirom. Konzumacija ROO smanjila je koncentraciju malondialdehida za 18% u svih ispitanika, dok je
konzumacija EVOO smanjila koncentracije hsCRP za 151% i brzinu sedimentacije eritrocita za 62% u ispitanika
liječenih inhibitorima proteaze. Koncentracije hsCRP-a značajno su smanjene nakon konzumacije EVOO samo u
ispitanika čija je suradljivost bila veća od 90%. Konzumacija maslinovih ulja nije smanjila rizik za koronarnu
bolest srca i metabolički sindrom. Rizične čimbenike za kardiovaskularne bolesti potrebno je definirati i pratiti
tijekom antiretrovirusnog liječenja. Učinkovitost EVOO trebalo bi potvrditi na većem broju ispitanika.

Abstract (english)

Premature atherosclerosis in HIV infected patients is associated with chronic infection by itself and side effects
of antiretroviral therapy. Beneficial effect of extra virgin olive oil (EVOO) could decrease the risk for
cardiovascular disease in HIV-infected patients. 39 HIV positive male participants were included in randomized
crossover controlled trial. They consumed EVOO and refined olive oil (ROO) - placebo. The atherosclerosis risk
factors were affected in more than 50% of participants receiving antiretroviral therapy. In more than 90% of
participants malondialdehyde concentrations and superoxide dismutase cathalitic concentrations were increased.
Risk factors were more affected in participants using protease inhibitors and abacavir containing antiretroviral
therapy. After ROO administration, MDA concentration was 18% higher when compared to basic values. After
EVOO administration, in participants using protease inhibitors containing antiretroviral therapy, erythrocyte
sedimentation rate and hsCRP concentrations were 62% and 151% lower when compared to basic values,
respectively. hsCRP concentrations showed a significant decrease after EVOO administration only in
participants with >90% compliance. Olive oil consumption did not affect the risk for coronary heart disease and
the metabolic syndrome diagnosis. Cardiovascular disease risk factors should be recognized and followed in all
HIV patients receiving antiretroviral therapy. EVOO effects should be confirmed on a larger sample size.

• Keywords: ekstra djevičansko maslinovo ulje; virus humane imunodeficijencije; upala; biljezi ateroskleroze; antiretrovirusno liječenje
• Keywords (english): extra virgin olive oil; human immunodeficiency virus; inflammation; atherosclerosis biomarkers; antiretroviral therapy
• Language: croatian
• URN:NBN: urn:nbn:hr:163:750911
• Study programme: Title: Pharmacy and biochemistry; Study programme type: university; Study level: postgraduate; Academic / professional title: doktor znanosti (doktor znanosti)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2016-11-16 10:19:44