Cink i mangan u kapsuliranim dodacima prehrani za liječenje upalnih bolesti crijeva

master's thesis

• Title (english): Zinc and manganese in encapsulated food supplements for the treatment of inflammatory bowel diseases
• Author: Srećko Mandić
• Mentor: Daniela Amidžić Klarić (mentor)
• Committee member: Daniela Amidžić Klarić (predsjednik povjerenstva)
• Committee member: Ana Mornar Turk (član povjerenstva)
• Committee member: Domagoj Kifer (član povjerenstva)
• Granter: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of pharmaceutical analysis); Zagreb
• Defense date and country: 2024-09-13, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract

U današnje vrijeme raste uporaba dodataka prehrani za liječenje upalnih bolesti crijeva koji sadrže
justiciju, kurkumu i indijski tamjanovac. S obzirom na važnost određivanja kvalitete dodataka
prehrani, cilj ovog rada bio je odrediti koncentracije mangana i cinka u kapsuliranim dodacima
prehrani te usporediti njihov sadržaj između tvrdih i mekih kapsula. Koncentracije cinka i mangana
analizirane su metodom atomske apsorpcijske spektrometrije, korištene su plamena i grafitna
tehnika. Uzorci su prethodno pripremljeni mikrovalnom digestijom radi osiguravanja homogenosti
uzorka i preciznosti analize. Dobiveni rezultati pokazali su da su koncentracije cinka i mangana
unutar dozvoljenih granica propisanih međunarodnim smjernicama. Uočeno je da su koncentracije
mangana više u kapsulama koje sadrže usitnjenu biljnu drogu, dok su koncentracije cinka značajno
više u mekim kapsulama. Zaključeno je da uzorci ispunjavaju sigurnosne standarde te da su prikladni
za uporabu u terapiji upalnih bolesti crijeva.

Abstract (english)

Nowadays, the use of dietary supplements containing Justicia, turmeric, and Indian frankincense for
treating inflammatory bowel diseases is increasing. Given the importance of determining the quality
of dietary supplements, the aim of this study was to determine the concentrations of manganese and
zinc in encapsulated dietary supplements and to compare their content between different types of
capsules. Zinc and manganese concentrations were analyzed using atomic absorption spectrometry,
employing flame and graphite techniques. Samples were pre-treated with microwave digestion to
ensure homogeneity and accuracy of the analysis. The results showed that zinc and manganese
concentrations were within the permissible limits set by international guidelines. It was observed
that manganese concentrations were higher in capsules containing ground plant material, while zinc
concentrations were significantly higher in soft capsules. It was concluded that the samples meet
safety standards and are suitable for use in the treatment of inflammatory bowel diseases.

• Keywords: mangan; cink; upalne bolesti crijeva; dodaci prehrani; kurkuma; indijski tamjanovac; justicija
• Keywords (english): zinc; manganese; inflammatory bowel diseases; dietary supplements; Turmeric; Green chiretta; Indian frankincense
• Language: croatian
• URN:NBN: urn:nbn:hr:163:997636
• Study programme: Title: Pharmacy - integrated undergraduate and graduate - university study; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: sveučilišni magistar farmacije (sveučilišni magistar farmacije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Embargoed access; Embargo expiration date: 2026-09-13
• Created on: 2025-04-24 09:00:46