Niosomi kao terapijski nanosustavi za primjenu lijeka

master's thesis

• Title (english): Niosomes as drug delivery nanosystems
• Author: Ivan Krezo
• Mentor: Ivan Pepić (mentor)
• Committee member: Ivan Pepić (predsjednik povjerenstva)
• Committee member: Anita Hafner (član povjerenstva)
• Committee member: Erim Bešić (član povjerenstva)
• Granter: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of pharmaceutical technology); Zagreb
• Defense date and country: 2016-09-30, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract

Niosomi su vezikularni terapijski sustavi nanometarskog reda veličine koji posljednjih 30 godina
značajno privlače pozornost i sve su češći predmet studija i kliničkih ispitivanja. Obzirom da je
optimizacija efikasnosti, bioraspoloživosti i sigurnosti primjene lijeka stalan izazov u farmaceutici,
niosomi kao nosači terapijskog sustava u teoriji predstavljaju veliki potencijal za siguran, efikasan,
selektivan i jeftin terapijski sustav. Uklapanjem lijeka u niosome mijenjaju se fizikalno-kemijska i
biofarmaceutska svojstva lijeka. Uzevši u obzir da su niosomi podložni brojnim modifikacijama,
lijek uklopljen u niosome postaje efikasniji i prikladniji za više puteva primjene. Relevantna
istraživanja, koja su u ovom istraživanju selektivno sumirana, govore o svim prednostima niosoma
kao terapijskih sustava, usporedbi niosoma sa liposomskim vezikularnim sustavima, metodama
pripreme, pročišćavanja i karakterizaciji niosoma, kao i mogućim putevima primjene istih od
kojim su u fokusu dermalna/transdermalna primjena i primjena u antitumorskoj terapiji.

Abstract (english)

Niosomes are nano scale vesicular drug delivery system and has attracted a lot of attention in the
last 30 years. Considering optimisation of drug safety, bioavailability and efficiency, there are
more and more new researches and studies on this topic novadays. Niosomes represents potential
to develope into a safe, efficient, target selective and low cost drug delivery system. Incaspulating
in niosomes, physical and chemical properties of drug are changed. Considering niosomes as easyto-
modify system, incapsulated drug becomes more efficient and suitable for various deliery
routes. This review summs up some relevant studies and contains inforamtions about advantages
of niosomes as drug delivery system, methods of preparation, purification,
characterisation/evaluation and their use by various routes of administration with emphasis on
dermal/transdermal route and therapeutic application in cancer therapy.

• Keywords: niosomi; slabo topljivi lijekovi; ograničena bioraspoloživost; komercijalna tehnologija; primjena lijeka; komercijalni nanokristalni lijekovi
• Keywords (english): niosomes; poorly soluble drugs; limited bioavailability; commercial technologies; drug delivery; commercial drug nanocrystal products
• Language: croatian
• URN:NBN: urn:nbn:hr:163:915898
• Study programme: Title: Pharmacy; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: magistar/magistra farmacije (magistar/magistra farmacije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Access restricted to students and staff of home institution
• Created on: 2016-12-06 13:23:46