Terapijski potencijal huperzina A i njegovih derivata u liječenju Alzheimerove bolesti

master's thesis

• Title (english): Therapeutic potential of huperzine A and its derivatives in the treatment of Alzheimer's disease
• Author: Katarina Zemljak
• Mentor: Biljana Blažeković (mentor)
• Committee member: Biljana Blažeković (predsjednik povjerenstva)
• Committee member: Sanda Vladimir-Knežević (član povjerenstva)
• Committee member: Željka Vanić (član povjerenstva)
• Granter: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of pharmacognosy); Zagreb
• Defense date and country: 2017-09-01, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract

Cilj ovog diplomskog rada bio je prikupiti, sistematizirati i prikazati dosadašnje znanstvene spoznaje o pretkliničkim i kliničkim dokazima djelotvornosti huperzina A i njegovih derivata. Huperzin A je alkaloid izoliran iz kineske huperzije (Huperzia serrata (Thunb .) Trevis.), ljekovite biljke s dugom tradicijom primjene u kineskoj medicini. Rezultati dosadašnjih pretkliničkih i kliničkih istraživanja potvrđuju da se može ubrojiti među najpotentnije inhibitore acetilkolinesteraze uz znatno bolja farmakokinetička svojstva i profil nuspojava u odnosu na druge inhibitore koji se trenutno koriste u terapiji Alzheimerove bolesti. Također postoje dokazi o njegovom neuroprotektivnom djelovanju. Noviji derivati huperzina A, posebice molekula ZT-1 koja se smatra prolijekom huperzina A, pokazuju još potentnije antiacetilkolinesterazno djelovanje i slabije izražene nuspojave, a inovativne parenteralne formulacije olakšavaju primjenu ovih potencijalnih novih lijekova kod pacijenata koji boluju od demencije. Iako značajan broj kliničkih ispitivanja potvrđuje povoljan učinak huperzina A na kognitivne funkcije i svakodnevne životne aktivnosti kod oboljelih, potrebna su daljnja, rigoroznija i veća klinička istraživanja koja će pružiti dodatne, dovoljno čvrste dokaze potrebne da bi huperzin A ili njegov derivat postao novi lijek za Alzheimerovu bolest.

Abstract (english)

The objective of this study was to collect, systematize and provide recent scientific knowledge on preclinical and clinical evidence of the efficacy of huperzine A and its derivatives. Huperzin A is an alkaloid isolated from Huperzia serrata (Thunb.) Trevis., the Chinese medicinal herb with a long tradition of use in Chinese medicine. The results of available preclinical and clinical studies confirm that it can be counted among the most potent acetylcholinesterase inhibitors with significantly better pharmacokinetic properties and side effects profile compared to other inhibitors currently used in Alzheimer's disease therapy. There is also evidence of its neuroprotective action. Newer derivatives of huperzine A, especially the ZT-1 molecule that is considered a prodrug of huperzine A, showed even more potent antiacetylcholinesterase activity and weaker side effects, and innovative parenteral formulations facilitate the application of these potential new drugs in patients suffering from dementia. Although a significant number of clinical trials confirm the beneficial effect of huperzine A on cognitive functions and daily life activities in patients, further, more rigorous and larger clinical studies are needed to provide additional, sufficiently solid evidence necessary to make huperzine A or its derivative a new drug for Alzheimer's disease.

• Keywords: huperzin A; Huperzia serrata; Alzheimerova bolest
• Keywords (english): huperzine A; Huperzia serrata; Alzheimer's disease
• Language: croatian
• URN:NBN: urn:nbn:hr:163:027276
• Study programme: Title: Pharmacy; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: magistar/magistra farmacije (magistar/magistra farmacije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2017-11-28 11:13:23