Određivanje antiagregacijskog učinka etanolnih ekstrakata lista matičnjaka

master's thesis

• Title (english): Determination of antiaggregatory effect of ethanolic extracts of lemonbalm leaves
• Author: Ivan Novaković
• Mentor: Mirza Bojić (mentor)
• Committee member: Mirza Bojić (predsjednik povjerenstva)
• Committee member: Željan Maleš (član povjerenstva)
• Committee member: Miranda Sertić (član povjerenstva)
• Granter: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of medicinal chemistry); Zagreb
• Defense date and country: 2017-05-02, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract

Kardiovaskularne bolesti uzimaju sve više života i povećavaju teret zdravstvenih sustava. Pacijenti s poviješću
tromboembolijskih poremećaja moraju dulje vremena, a nekad i doživotno uzimati antiagregacijsku terapiju koja
uzrokuje raznovrsne nuspojave. Sigurna i učinkovita farmakoterapija tromboembolijskih bolesti jedan je od važnih
ciljeva farmaceutske struke čijim bi se ostvarenjem postiglo i smanjenje potrošnje zdravstvenih sustava.
Polifenoli, posebice flavonoidi, su spojevi koji se nalaze u biljkama i koji posebno obećavaju kad su u pitanju
prevencija i terapija raznih kardiovaskularnih pa tako i tromboembolijskih bolesti. Matičnjak je mediteranska biljka s
dugo poznatim blagotvornim svojstvima. U ovome radu proučavao se antiagregacijski učinak etanolnog ekstrakta lista
matičnjaka, a metoda koja se koristila je trombocitna impedancijska agregometrija.
Nakon podvrgavanja dobivenih rezultata statističkoj analizi zaključuje se da ekstrakt matičnjaka ima zamjetno
antiagregacijsko djelovanje koje bi se moglo iskoristiti za daljnja istraživanja koja su potrebna kako bi se u potpunosti
razumjelo na koji se način događa inhibicija agregacije i kako bi se našao način da se ove spoznaje potencijalno
primjene u farmakoterapiji tromboembolijskih bolesti.

Abstract (english)

Cardiovascular diseases take the increasing nuber of lives and increase the burden on healthcare systems. Patients with history of thromboembolic disorders must take antiaggregatory therapy for extended periods of time and sometimes for life. That therapy can cause various side effects. Safe and efficient pharmacotherapy of the thromboembolic disorders is one of the important goals of pharmacy which, if achieved, would lead to decrease of expenditure in healthcare. Polyphenols and especially flavonoids are compounds found in plants which show the most promise when prevention and therapy of various cardiovascular diseases and therefore thromboembolic disorders is considered. Lemonbalm is mediterranean plant with long known beneficial properties. This thesis studies the antiaggregatory effect of ethanolic extract of lemonbalm leaves. The method used to measure that effect was impedance aggregometry. After statistical analysis of the results it can be concluded that lemonbalm extract does have a notable antiaggregatory properties that should be examined further in the future research which is neccessary to gain a full understanding of the mechanism in which the inhibition of aggregation takes place and to find a suitable way in which these findings could be used in the pharmacotherapy of thromboembolic disorders.

• Keywords: matičnjak; antiagregacijsko djelovanje; impedancijska agregometrija
• Keywords (english): lemonbalm; antiaggregatiory effect; impedance aggregometry
• Language: croatian
• URN:NBN: urn:nbn:hr:163:999879
• Study programme: Title: Pharmacy; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: magistar/magistra farmacije (magistar/magistra farmacije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2017-11-29 11:34:28