Dissolution of celecoxib from mucoadhesive disks based on polyaspartamide derivatives

Scientific paper - Original scientific paper

• Title (croatian): Oslobađanje celekoksiba iz mukoadhezivnih diskova s polimerima poliaspartamidnog tipa
• Author: Davorka Ballian Krznar
• Author: Jelena Filipović-Grčić
• Author: Branka Zorc
• Author: Marijana Zovko
• Author's institution: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of medicinal chemistry)
• Author's institution: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of pharmaceutical technology)
• Author's institution: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of pharmacognosy)
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract (english)

A series of mucoadhesive disks with celecoxib as a model drug of very low aqueous solubility were prepared and characterized. Two polymers of polyaspartamide type, poly,-(N-2-hydroxyethyl-DL-aspartamide) (PHEA, 1) and its thiolated analogue poly[α,β-(N-2-hydroxyethyl-DL-aspartamide)]-poly[α,β-(N-2-thioethyl-DL-aspartamide)] copolymer (PHTA, 2a,b), and two commercially available polymers Carbopol 934P and hydroxypropylmethyl cellulose 4000 were used as excipients. Disks containing a mixture of equivalent amounts of thiomer 2b and Carbopol 934P as an excipient exhibited the highest dissolution rate.

Abstract (croatian)

Pripravljeni su i karakterizirani mukoadhezivni diskovi s celekoksibom kao lipofilnom modelnom supstancijom. Kao ekscipiensi uporabljena su dva polimera poliaspartamidnog tipa, poli[α,β-(N-2-hidroksietil-DL-aspartamid) (PHEA, 1) i njegov tiolirani analog poli[α,β-(N-2-hidroksietil-DL-aspartamid)]-poli[α,β-(N-2-tioetil-DL-aspartamid)] kopolimer (PHTA, 2a,b), te dva komercijalno dostupna polimera Carbopol 934P i hidroksipropilmetilceluloza 4000. Najbolji profil oslobađanja celekoksiba postignut je iz diskova sastavljenih od tiomera 2b i Carbopola 934P u masenom omjeru 1:1.

• Keywords (english): celecoxib; disks; polyaspartamide; thiomer
• Keywords (croatian): celekoksib; diskovi; poliaspartamid; tiomer
• Language: english
• Publication type: Scientific paper - Original scientific paper
• Publication status: Published
• Peer review: Peer review - international
• Publication version: Published version
• Journal title: Acta Pharmaceutica
• Numbering: vol. 56, no. 4, pp. 463-470
• p-ISSN: 1330-0075
• e-ISSN: 1846-9558
• URN:NBN: urn:nbn:hr:163:769901
• Publication: 2006-12-01
• Document URL: https://hrcak.srce.hr/4608
• Type of resource: Text
• Access conditions: Open access
• Created on: 2018-02-14 13:50:24