Ciklodekstrini - nosači lijekova

Stručni rad - Stručni rad

• Autor: Mario Jug
• Autor: Mira Bećirević-Laćan
• Autorova ustanova: Sveučilište u Zagrebu; Farmaceutsko-biokemijski fakultet; (Zavod za farmaceutsku tehnologiju)
• Znanstveno / umjetničko područje, polje i grana: BIOMEDICINA I ZDRAVSTVO; Farmacija; Farmacija

Sažetak (engleski)

Cyclodextrins are cyclic oligosaccharides with hydrophilic outer surface
and lipophilic central cavity able to form inclusion complexes with many lipophilic
in water-insolubile drugs. In the solutions drug molecules located in
the central cavity are in dynamic equilibrium with free drug molecules. Due
to the cyclodextrins size and hydrophilicity only insignificant amounts of
cyclodextrins will be able to penetrate across the biological barriers and only
free drug will be absorbed. Cyclodextrins are very useful pharmaceutical
excipients, able to improve drug solubility and stability and modify sensory
characteristics such as unpleasant taste and smell of the drug. Recently
cyclodextrins are used in design of advanced dosage forms. The hydrophylic
and ionizable cyclodextrins can serve as potent drug carrie;rs in the immediate release- and delayed release - formulations, while the release rate of water-
soluble drugs can be retarded by hydrophobic cyclodextrins. The combination
of molecular incapsulation with other carrier materials will become
effective and valuble tool in the improvement of the drug formulation. Moreover,
the most desirable attribute for the drug carrier is its ability to deliver
drug to a targeted site: conjugates of a drug with cyclodextrin can be
used in colon drug delivery. On the basis of this knowledge, it can be expected
that cyclodextrins will play an important role in design of advanced drug
formulations .

• Ključne riječi (hrvatski): ciklodekstrini; inkluzijski kompleksi; derivati ciklodekstrina; kontrolirano oslobađanje ljekovite tvari
• Jezik: hrvatski
• Vrsta publikacije: Stručni rad - Stručni rad
• Status objave: Objavljen
• Vrsta recenzije: Recenziran - domaća recenzija
• Verzija publikacije: Objavljena verzija rada (izdavačev PDF)
• Naslov časopisa: Farmaceutski glasnik
• Brojčani podaci: vol. 58, br. 6, str. 189-204
• p-ISSN: 0014-8202
• URN:NBN: urn:nbn:hr:163:611606
• Datum objave publikacije: 2002
• Vrsta resursa: Tekst
• Prava pristupa: Otvoreni pristup
• Datum i vrijeme pohrane: 2021-03-04 11:49:17