Direktno komprimiranje - postupak izrade tableta

Stručni rad - Stručni rad

• Autor: Marina Pulišić
• Autor: Romana Senjković; MBZ: 42855
• Autorova ustanova: Sveučilište u Zagrebu; Farmaceutsko-biokemijski fakultet; (Zavod za farmaceutsku tehnologiju)
• Znanstveno / umjetničko područje, polje i grana: BIOMEDICINA I ZDRAVSTVO; Farmacija; Farmacija

Sažetak (engleski)

Direct compression is a recent procedure of producing tablets. Its advantages
are greater than its disadvantages. Direct compression is enabled by addition
of various :fillers of good compressibility and flowability. These agents are
mostly of organic origin, soluble or insoluble in water. Among the soluble diluents
(fillers) commercially available are the following: lactose, saccharose,
dextrose, sorbitol, mannitol. Other additives used in direct compression formules
include insoluble cellulose and inorganic calcium salts. These agents are
most often various modifications. Materials serving as disintegrants have been
classified as starches, celluloses, PVP and their modifications. Commonly used
lubricants include magnesium stearate and hydrogenated vegetable oils. Approaches
being used to make direct compression universally include material of
good flowability, cohesivity, porosity, and mixing characteristic. Great attention
has to be paid to the tablet characteristic, especially to tablet hardness and content
uniformity of the drugs.

• Ključne riječi (hrvatski): granulacija; direktno tabletiranje; granula; tableta
• Jezik: hrvatski
• Vrsta publikacije: Stručni rad - Stručni rad
• Status objave: Objavljen
• Vrsta recenzije: Recenziran - domaća recenzija
• Verzija publikacije: Objavljena verzija rada (izdavačev PDF)
• Naslov časopisa: Farmaceutski glasnik
• Brojčani podaci: vol. 49, br. 6, str. 167-175
• p-ISSN: 0014-8202
• URN:NBN: urn:nbn:hr:163:945745
• Datum objave publikacije: 1993
• Vrsta resursa: Tekst
• Prava pristupa: Otvoreni pristup
• Datum i vrijeme pohrane: 2021-03-16 16:46:13