Fitokemijski sastav i biološki učinci gljive Cordyceps sinensis (Berk.) Sacc.

professional thesis

• Author: Josip Zekić
• Mentor: Sanda Vladimir-Knežević (mentor)
• Committee member: Marijana Zovko Končić (predsjednik povjerenstva)
• Committee member: Sanda Vladimir-Knežević (član povjerenstva)
• Committee member: Antun Alegro (član povjerenstva)
• Granter: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of pharmacognosy); Zagreb
• Defense date and country: 2018-05-10, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract

Cilj istraživanja
Cilj ovog specijalističkog rada je pregled podataka o bioaktivnim sastavnicama i
farmakološkim učincima kineskog kordicepsa da se ustanovi postoje li znanstveni temelji za
tradicionalnu uporabu ove gljive te koja pitanja ostaju otvorena za daljnja istraživanja.
Materijal i metode
Istraživanje u okviru ovog rada je teorijskog karaktera i uključuju pregled dostupne znanstvene
i stručne literature o predloženoj temi. U pretraživanju su korištene relevantne elektronske
mrežne stranice te bibliografske baze podataka kao što su: Current Contents, ScienceDirect,
Scopus, PubMed, Medline i Cocharen Library.
Rezultati
Cordyceps sinensis (Berk.) Sacc. je ljekovita gljiva koja već stoljećima zauzima značajno
mjesto u tradicionalnoj kineskoj medicini. Entomopatogena je gljiva rasprostranjena na
Tibetanskoj visoravni i Himalajima. Nukleozidi, polisaharidi i steroli identificirani su kao
glavne bioaktivne sastavnice. Brojne pretkliničke i nekoliko kliničkih studija pokazale su da
ekstrakti kineskog kordicepsa te izolirani polisaharidi i kordicepin posjeduju antioksidativnu,
protuupalnu, imunomodulacijsku i antitumorsku aktivnost, reguliraju glikemiju i metabolizam
lipida te jačaju fizičku izdržljivost i smanjuju osjećaj umora.
Zaključci
Mnogi znanstveni dokazi upućuju na blagotvorne učinke kineskog kordicepsa na ljudsko
zdravlje, Međutim, potrebne su buduće kliničke studije kojima će se ustanoviti njegova
terapijska učinkovitost i sigurnost primjene.

Abstract (english)

Objectives
The purpose of this specialist work is to review the data on bioactive constituents and the
pharmacological effects of Chinese cordyceps to determine if there are scientific bases for the
traditional use of this fungus and what issues remain open for further research.
Material and methods
Research in this paper is a theoretical one and includes a detailed overview of the available
professional and scientific data on the topic. Relevant websites and bibliographic database such
as Current Contents, ScienceDirect, Scopus, PubMed, Medline and Lexicomp are searched.
Results
Cordyceps sinensis (Berk.) Sacc. is a medicinal mushroom which has been a highly regarded
cornerstone of Chinese medicine for centuries. It is an entamophagus fungus, naturally
distributed in the Tibetan Plateau and Himalayas. Nucleosides, polysaccharides and sterols
detected as the major bioactive constituents. Numerous preclinical and several clinical studies
have shown that cordyceps extracts, isolated polysaccharides and cordycepin possess
antioxidative, anti-inflammatory, immunomodulatory and antitumor activity, regulate glycemia
and lipid metabolism, and enhance physical endurance and reduce fatigue.
Conclusion
Much scientific evidence shows the beneficial effects of Chinese cordyceps on human health.
However, further clinical trials are required to establish therapeutic its efficacy and safety in
humans.

• Keywords: kineski kordiceps; Cordyceps sinensis (Berk.) Sacc.
• Keywords (english): Chinese cordyceps; Cordyceps sinensis (Berk.) Sacc.
• Language: croatian
• URN:NBN: urn:nbn:hr:163:706365
• Study programme: Title: Phytopharmacy with dietotherapy; Study programme type: university; Study level: postgraduate specialist; Academic / professional title: sveučilišni magistar/sveučilišna magistra fitofarmacije s dijetoterapijom (sveučilišni magistar/sveučilišna magistra fitofarmacije s dijetoterapijom)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2019-03-06 14:47:43