Razlike između hemangioma i vaskularnih malformacija i farmakoterapija u djece

master's thesis

• Title (english): Differences between hemangioma and vascular malformation and pharmacotherapy in children
• Author: Marija Pešić
• Mentor: Petra Turčić (mentor)
• Mentor: Arnes Rešić (mentor)
• Committee member: Petra Turčić (predsjednik povjerenstva)
• Committee member: Marija Grdić Rajković (član povjerenstva)
• Committee member: Arnes Rešić (član povjerenstva)
• Granter: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of pharmacology); Zagreb
• Defense date and country: 2019-09-19, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract

Dojenački hemangiom je benigni vaskularni tumor sa visokom incidencijom u djece, karakterizira ga abnormalna proliferacija endotelnih stanica kao i abnormalna arhitektura krvnih žila. Vaskularne malformacije su urođene pogreške vaskularne morfogeneze, prisutne su odmah nakon rođenja. Kako bi se spriječile pogreške u dijagnozi i liječenju, potrebno je detaljno razlikovati ove dvije skupine vaskularnih anomalija. U liječenju infantilnog hemangioma, najučinkovitiji je oralno primijenjen propranolol, dok se liječenje vaskularnih malformacija provodi laserski, skleroterapijom, kirurškim procesima, embolizacijom i rjeđe farmakoterapijom. Zbog česte pojavnosti na području lica i vrata, ove anomalije uvelike definiraju fizički izgled pacijenta pa mogu utjecati na njegov psihološki profil i samopouzdanje. Kako bi se optimizirala terapija, nužna su dodatna znanstvena istraživanja mehanizama nastajanja ovih bolesti kao i detaljnih mehanizma djelovanja primijenjenih lijekova.

Abstract (english)

Infantile hemangioma is benign vascular tumor with high incidence and is characterized by abnormal endothelial cell proliferation as well as abnormal blood vessel architecture. Vascular malformations are congenital errors of vascular morphogenesis, present immediately after birth. To prevent errors in diagnosis and treatment, these two groups of vascular anomalies need to be precisely differentiated. In the treatment of infantile hemangioma, the most effective therapy is orally administered propranolol, while the treatment of vascular malformations is performed by laser, sclerotherapy, surgical processes, embolization and rarely pharmacotherapy. Because of their frequent appearance in the face and neck area, these anomalies greatly define physical appearance of the patient and can affect his psychological profile and self-confidence. In order to achieve optimal therapy additional scientific research is needed to clarify the mechanisms of these diseases as well as the detailed mechanisms of action of the drugs administered.

• Keywords: dojenački hemangiom; vaskularne malformacije; liječenje vaskularnih anomalija; propranolol
• Keywords (english): infantile hemangioma; vascular malformations; vascular anomalies management; propranolol
• Language: croatian
• URN:NBN: urn:nbn:hr:163:979918
• Study programme: Title: Pharmacy; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: magistar/magistra farmacije (magistar/magistra farmacije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2020-03-05 13:23:50