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Scientific paper - Review paper
Nucleofugality of leaving groups
Croatica Chemica Acta, 90 (2017), 4; 571-581. https://doi.org/10.5562/cca3283
Matić, Mirela; Denegri, Bernard; Jurić, Sandra; Kronja, Olga

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Matić, M., Denegri, B., Jurić, S. & Kronja, O. (2017). Nucleofugality of leaving groups. Croatica Chemica Acta, 90. (4), 571-581. doi: 10.5562/cca3283

Matić, Mirela, et al. "Nucleofugality of leaving groups." Croatica Chemica Acta, vol. 90, no. 4, 2017, pp. 571-581. https://doi.org/10.5562/cca3283

Matić, Mirela, Bernard Denegri, Sandra Jurić and Olga Kronja. "Nucleofugality of leaving groups." Croatica Chemica Acta 90, no. 4 (2017): 571-581. https://doi.org/10.5562/cca3283

Matić, M., et al. (2017) 'Nucleofugality of leaving groups', Croatica Chemica Acta, 90(4), pp. 571-581. doi: 10.5562/cca3283

Matić M, Denegri B, Jurić S, Kronja O. Nucleofugality of leaving groups. Croatica Chemica Acta [Internet]. 2017 [cited 2024 November 15];90(4):571-581. doi: 10.5562/cca3283

M. Matić, B. Denegri, S. Jurić and O. Kronja, "Nucleofugality of leaving groups", Croatica Chemica Acta, vol. 90, no. 4, pp. 571-581, 2017. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:163:396284. [Accessed: 15 November 2024]

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Metadata
Title (english)Nucleofugality of leaving groups
AuthorMirela Matić
AuthorBernard Denegri
AuthorSandra Jurić
AuthorOlga Kronja
Author's institutionUniversity of Zagreb
Faculty of Pharmacy and Biochemistry
(Department of organic chemistry)
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Organic Chemistry
Abstract (english)
In this short authors' review, a method for determining experimental and calculated nucleofugalities of leaving groups in a given solvents according to LFER equation log k = sf (Nf + Ef) is presented. Also, a comprehensive overview of the experimental and calculated nucleofuges specific parameters (Nf and sf) for various negatively charged and neutral leaving groups is shown. Some applications of the above method have been demonstrated: use of the electrofugalitiy and nucleofugality scales to estimate the reactivities of a variety of substrates in various solvents, as well as assessment whether a given substrate is stable in a given solvent for a sufficent amount of time, which may indicate if the substrate can be handled in the solvent of choice during synthetic and other procedures. The method can also be used to establish whether the relative reactivity of leaving groups depends on the electrofuge moiety of the substrate. <br><a rel="license" href="http://creativecommons.org/licenses/by/4.0/"><img alt="Creative Commons License" style="border-width:0" src="https://i.creativecommons.org/l/by/4.0/80x15.png" /></a> This work is licensed under a <a rel="license" href="http://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution 4.0 International License</a>.
Keywords (english)
Languageenglish
Publication typeScientific paper - Review paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleCroatica Chemica Acta
Numberingvol. 90, no. 4, pp. 571-581
p-ISSN0011-1643
e-ISSN1334-417X
DOIhttps://doi.org/10.5562/cca3283
URN:NBNurn:nbn:hr:163:396284
Publication2017
Document URLhttps://hrcak.srce.hr/198666
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2020-04-14 16:50:45