Hormonsko starenje kože

Professional paper - Professional paper

• Author: Ivan Pepić
• Author: Tereza Sinovčić
• Author: Jelena Filipović-Grčić
• Author's institution: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of pharmaceutical technology)
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract (english)

The ageing of skin occurs i n a l i individuals at a variable rate that is influenced by
genetic, environmental and hormonal factors. The ageing process can be divided into
intrinsic ageing (due to genetic factors and alterations of the endocrine environment -
hormonal ageing) and extrinsic ageing (mainly attributed to ultraviolet radiation - photoageing
or actinic ageing). With increasing age the epidermis, the dermis and skin appendages
progressively lose their youthful properties and abilities; the skin gradually loses
its structural and functional characteristics. Hormones are decisively involved in intrinsic
ageing. Over time important circulating hormones decline due to a reduced secretion
of the pituitary, adrenal glands and the gonads or due to an intercurrent disease. The
declining estrogen level, that accompaines menopause exacerbates the deleterious effects
on both intrinsic and extrinsic skin ageing. Estrogens are C-1 8 steroids synthesized
from cholesterol in the ovary add/or in the peripheral tissue. Two estrogen receptors
(ERa and ER/3) have been detected in the skin. Estrogens improve skin in many ways
(e.g. increase collagen, elastin and glycosaminoglycans content; increase dermal and epidermal
skin thickness; improve skin moisture, enhance epidermal barrier function, decrease
alterations in elasticity of the skin). Estrogens regulate skin pigmentation and reduce the
production of sebum. Estrogens accelerate wound healing, although their role is complex
and not fully understood. The use of hormone replacement therapy (H RT) in the
older population leads to a scaring profile similar to young population both macroscopically
and microscopically. Although, older women who use HRT may have healthier and
younger skin appearance than non-users and may he at lower risk for the development of
dermatoses, further work is necessary before valid conclusions can he drawn regarding
the risk and benefits of topical, oral estrogens or HRT application in the prevention of
the hormonal skin ageing. However, because of the possible serious side effects of HRT
(especially the increased risk of thromho-embolic accidents and breast cancer) there is a
growing demand for alternative treatments, such as phytoestrogens (isoflavones and
lignans). They have positive estrogen-like effect with fewer adverse effects.

• Keywords (croatian): koža; starenje kože; estrogeni; menopauza; hormonska nadomjesna terapija; HNT
• Language: croatian
• Publication type: Professional paper - Professional paper
• Publication status: Published
• Peer review: Peer review - domestic
• Publication version: Published version
• Journal title: Farmaceutski glasnik
• Numbering: vol. 67, no. 1, pp. 11-26
• p-ISSN: 0014-8202
• URN:NBN: urn:nbn:hr:163:321519
• Publication: 2011
• Type of resource: Text
• Access conditions: Open access
• Created on: 2020-07-08 15:25:33