Terapijski sustavi kontroliranog oslobađanja u debelom crijevu

Professional paper - Review paper

• Author: Željka Pavelić
• Author: Biljana Nigović
• Author: Petra Konosić
• Author: Mira Bećirević-Laćan
• Author's institution: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of pharmaceutical analysis)
• Author's institution: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of pharmaceutical technology)
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract (english)

Colon-specific drug delivery systems offer several potential therapeutic advantages. In
a number of colonic diseases such as colorectal cancer, Crohn's disease and spastic
colon, it has been shown that local is more effective than systemic delivery. Colonic drug
delivery can be achieved by oral or by rectal administration. Rectal delivery forms
(suppositories and enemas) are not always effective because a high variability is observed
in the distribution of drugs administered by this route. Therefore, oral route is preferred.
Absorption and degradation of the active ingredient in the upper part of the gastrointestinal
tract (GIT) is the major obstacle with the delivery of drugs by oral route and
must be overcome for successful colonic drug delivery.
Drugs for which the colon is a potential absorption site (e.g. peptides and proteins)
can be delivered to this region for subsequent systemic absorption. The digestive enzymes
of the GIT generally degrade these agents. However, these enzymes are present in
significantly lower amounts in the colon compared with the upper portion of the GIT.
Colon-specific drug delivery has been attempted in a number of ways that primarily
seek to exploit the changes in the physiological parameters along the GIT. These approaches
include the use of prodrugs, pH-sensitive polymers, bacterial degradable polymers,
hydrogels and matrices, as well as multicoating time-dependent delivery systems.
The use of these strategies to target drug delivery to the colon is addressed in detail.

• Keywords (croatian): debelo crijevo; kontrolirano oslobađanje lijeka; apsorpcija lijeka; enzimatski kontrolirani terapijski sustavi; vremenom kontrolirani terapijski sustavi
• Language: croatian
• Publication type: Professional paper - Review paper
• Publication status: Published
• Peer review: Peer review - domestic
• Publication version: Published version
• Journal title: Farmaceutski glasnik
• Numbering: vol. 62, no. 9, pp. 455-469
• p-ISSN: 0014-8202
• URN:NBN: urn:nbn:hr:163:115350
• Publication: 2006
• Type of resource: Text
• Access conditions: Open access
• Created on: 2021-02-18 14:42:25