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Professional paper - Professional paper
Ciklodekstrini - nosači lijekova
Farmaceutski glasnik, 58 (2002), 6; 189-204. urn:nbn:hr:163:611606
Jug, Mario; Bećirević-Laćan, Mira

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Jug, M. & Bećirević Laćan, M. (2002). Ciklodekstrini - nosači lijekova. Farmaceutski glasnik, 58. (6), 189-204. Retrieved from https://urn.nsk.hr/urn:nbn:hr:163:611606

Jug, Mario and Mira Bećirević Laćan. "Ciklodekstrini - nosači lijekova." Farmaceutski glasnik, vol. 58, no. 6, 2002, pp. 189-204. https://urn.nsk.hr/urn:nbn:hr:163:611606

Jug, Mario and Mira Bećirević Laćan. "Ciklodekstrini - nosači lijekova." Farmaceutski glasnik 58, no. 6 (2002): 189-204. https://urn.nsk.hr/urn:nbn:hr:163:611606

Jug, M. and Bećirević Laćan, M. (2002) 'Ciklodekstrini - nosači lijekova', Farmaceutski glasnik, 58(6), pp. 189-204. Available at: https://urn.nsk.hr/urn:nbn:hr:163:611606 (Accessed 26 April 2024)

Jug M, Bećirević Laćan M. Ciklodekstrini - nosači lijekova. Farmaceutski glasnik [Internet]. 2002 [cited 2024 April 26];58(6):189-204. Available at: https://urn.nsk.hr/urn:nbn:hr:163:611606

M. Jug and M. Bećirević Laćan, "Ciklodekstrini - nosači lijekova", Farmaceutski glasnik, vol. 58, no. 6, pp. 189-204, 2002. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:163:611606. [Accessed: 26 April 2024]

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Metadata
Title (croatian)Ciklodekstrini - nosači lijekova
AuthorMario Jug
AuthorMira Bećirević-Laćan
Author's institutionUniversity of Zagreb
Faculty of Pharmacy and Biochemistry
(Department of pharmaceutical technology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Pharmacy
Pharmacy
Abstract (english)
Cyclodextrins are cyclic oligosaccharides with hydrophilic outer surface and lipophilic central cavity able to form inclusion complexes with many lipophilic in water-insolubile drugs. In the solutions drug molecules located in the central cavity are in dynamic equilibrium with free drug molecules. Due to the cyclodextrins size and hydrophilicity only insignificant amounts of cyclodextrins will be able to penetrate across the biological barriers and only free drug will be absorbed. Cyclodextrins are very useful pharmaceutical excipients, able to improve drug solubility and stability and modify sensory characteristics such as unpleasant taste and smell of the drug. Recently cyclodextrins are used in design of advanced dosage forms. The hydrophylic and ionizable cyclodextrins can serve as potent drug carrie;rs in the immediate release- and delayed release - formulations, while the release rate of water- soluble drugs can be retarded by hydrophobic cyclodextrins. The combination of molecular incapsulation with other carrier materials will become effective and valuble tool in the improvement of the drug formulation. Moreover, the most desirable attribute for the drug carrier is its ability to deliver drug to a targeted site: conjugates of a drug with cyclodextrin can be used in colon drug delivery. On the basis of this knowledge, it can be expected that cyclodextrins will play an important role in design of advanced drug formulations .
Keywords (croatian)
Languagecroatian
Publication typeProfessional paper - Professional paper
Publication statusPublished
Peer reviewPeer review - domestic
Publication versionPublished version
Journal titleFarmaceutski glasnik
Numberingvol. 58, no. 6, pp. 189-204
p-ISSN0014-8202
URN:NBNurn:nbn:hr:163:611606
Publication2002
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2021-03-04 11:49:17