Direktno komprimiranje - postupak izrade tableta

Professional paper - Professional paper

• Author: Marina Pulišić
• Author: Romana Senjković; MBZ: 42855
• Author's institution: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of pharmaceutical technology)
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract (english)

Direct compression is a recent procedure of producing tablets. Its advantages
are greater than its disadvantages. Direct compression is enabled by addition
of various :fillers of good compressibility and flowability. These agents are
mostly of organic origin, soluble or insoluble in water. Among the soluble diluents
(fillers) commercially available are the following: lactose, saccharose,
dextrose, sorbitol, mannitol. Other additives used in direct compression formules
include insoluble cellulose and inorganic calcium salts. These agents are
most often various modifications. Materials serving as disintegrants have been
classified as starches, celluloses, PVP and their modifications. Commonly used
lubricants include magnesium stearate and hydrogenated vegetable oils. Approaches
being used to make direct compression universally include material of
good flowability, cohesivity, porosity, and mixing characteristic. Great attention
has to be paid to the tablet characteristic, especially to tablet hardness and content
uniformity of the drugs.

• Keywords (croatian): granulacija; direktno tabletiranje; granula; tableta
• Language: croatian
• Publication type: Professional paper - Professional paper
• Publication status: Published
• Peer review: Peer review - domestic
• Publication version: Published version
• Journal title: Farmaceutski glasnik
• Numbering: vol. 49, no. 6, pp. 167-175
• p-ISSN: 0014-8202
• URN:NBN: urn:nbn:hr:163:945745
• Publication: 1993
• Type of resource: Text
• Access conditions: Open access
• Created on: 2021-03-16 16:46:13