Biološki učinci kapsaicina iz čili papričice

master's thesis

• Title (english): Biological effects of capsaicin from chili pepper
• Author: Damir Nemet
• Mentor: Kristina Radić (mentor)
• Committee member: Kristina Radić (predsjednik povjerenstva)
• Committee member: Dubravka Vitali Čepo (član povjerenstva)
• Committee member: Marijana Zovko Končić (član povjerenstva)
• Granter: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of food chemistry); Zagreb
• Defense date and country: 2022, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract

Kapsaicin je aktivna sastavnica ljute papričice (rod Capsicum, Solanaceae) s analgetskim svojstvima. Od svog otkrića,
koristi se kao homeopatski lijek za liječenje boli. Sustavni pregledi znanstvene literature potvrđuju da je kapsaicin
koristan u liječenju različitih kroničnih bolnih stanja. Novija istraživanja ukazuju na velik potencijal kapsaicina za
sistemsko liječenje brojnih drugih bolesti i stanja, kao što su pretilost, dijabetes ili metabolički sindrom no još uvijek
nema dovoljno znanstvenih dokaza koji bi opravdali njegovu upotrebu. No, pripravci s kapsaicinom se često koriste
iako je potrebno provesti više kliničkih studija za procjenjivanje učinaka ali i mogućih nuspojava korištenja kapsaicina
za pojedine indikacije.
Ovaj rad doprinosi razumijevanju mehanizma djelovanja, indikacija i potencijalnih štetnih učinaka kapsaicina što u
konačnici olakšava utvrđivanje prikladnosti pripravaka s kapsaicinom u ljekarničkoj praksi.
Zaključak rada je da je upotreba proizvoda s kapsaicinom opravdana u prevenciji bolesti uzrokovanih prekomjernom
tjelesnom masom te terapiji boli dok još uvijek nema dovoljno dokaza za upotrebu kapsaicina kao protutumorskog
agensa i u liječenju bolesti probavnog sustava. Također, prilikom savjetovanja pacijenata o preparatima s kapsaicinom,
nužno je upozoriti pacijenta na klinički značajne nuspojave te na ostala ograničenja primjene.

Abstract (english)

Capsaicin is an active ingredient in hot peppers (genus Capsicum, Solanaceae) with analgesic properties. Since its
discovery, it has been used as a homeopathic remedy to treat pain. Systematic reviews of the scientific literature
confirm that capsaicin is useful in the treatment of various chronic painful conditions. Recent research indicates the
great potential of capsaicin for the systemic treatment of many other diseases and conditions, such as obesity, diabetes
or metabolic syndrome, but there is still insufficient scientific evidence to justify its use. However, capsaicin
preparations are often used, although more clinical studies are needed to evaluate the effects and possible side effects
of capsaicin use for certain indications. This paper contributes to the understanding of the mechanism of action,
indications and potential adverse effects of capsaicin, which ultimately facilitates the determination of the suitability of
capsaicin preparations in pharmaceutical practice.
The paper concludes that the use of capsaicin products is justified in the prevention of overweight and pain therapy
while there is still insufficient evidence for the use of capsaicin as an antitumor agent and in the treatment of
gastrointestinal diseases. Also, when advising patients on capsaicin preparations, it is necessary to warn the patient of
clinically significant side effects and other limitations of use.

• Keywords: kapsaicin; karcinom; bol; artritis; čili papričica; gubitak tjelesne mase; probavni sustav
• Keywords (english): capsaicin; cancer; pain; arthritis; chili pepper; weight loss; gastrointestinal system
• Language: croatian
• URN:NBN: urn:nbn:hr:163:136120
• Study programme: Title: Pharmacy; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: magistar/magistra farmacije (magistar/magistra farmacije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2022-02-25 13:38:17