Načini prevencije, liječenja i prekrivanja kožnih problema uzrokovanih rozacejom

master's thesis

• Title (english): Methods of prevention, treatment and coverage of skin problems caused by rosacea
• Author: Nikolina Kvesić
• Mentor: Ivan Pepić (mentor)
• Committee member: Ivan Pepić (predsjednik povjerenstva)
• Committee member: Petra Turčić (član povjerenstva)
• Committee member: Lovorka Vujić (član povjerenstva)
• Granter: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of pharmaceutical technology); Zagreb
• Defense date and country: 2021-09-28, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract

Rozaceja je kronična upalna dermatoza karakterizirana rekurentnim naletima crvenila, trajnim eritemom te drugim kožnim obilježjima kao što su teleangiektazije, hrapavost, upalne papule i pustule te rjeđe fimatozne promjene. Prvenstveno zahvaća medijalni dio lica, uključujući obraze, nos, bradu i središnji dio čela, ali se ponekad može proširiti i na druge dijelove tijela, obično gornji dio trupa. Pacijenti koji boluju od rozaceje također mogu prezentirati i očne simptome. Najčešće pogađa osobe svjetlije puti, a javlja se između 30. i 50. godine života. Iako je patofiziologija rozaceje još uvijek nerazjašnjena, vjerojatno se radi o multifaktorijalnoj bolesti koju mogu izazvati te pogoršati različiti endogeni i egzogeni čimbenici. Manifestira se u nekoliko kliničkih oblika na temelju kojih se dijeli u četiri podtipa: eritematoteleangiektazijska, papulopustularna, fimatozna te okularna rozaceja. Najuvjerljivije dokaze o učinkovitosti terapije rozaceje imaju lokalna primjena brimonidina, ivermektina i azelatne kiseline te oralna primjena doksiciklina i izotretinoina.
Zbog činjenice da zahvaća lice, rozaceja ima negativan utjecaj na kvalitetu života i samopouzdanje oboljelih stoga je neizostavna i primjena dekorativne kozmetike. Uloga zdravstvenih djelatnika je savjetovanje pacijenata o pravilnoj njezi kože prikladnim kozmetičkim proizvodima, pridržavanju propisane terapije te izbjegavanju pogoršavajućih čimbenika, čime mogu značajno pridonijeti poboljšanju kvalitete života i psihičkog stanja bolesnika.

Abstract (english)

Rosacea is a chronic inflammatory dermatosis characterized by flushing, persistent erythema and other skin features such as telangiectasia, roughness, inflammatory papules and pustules, and less often phymatous changes. It primarily affects the medial part of the face, including the cheeks, nose, chin, and central part of the forehead, but can sometimes extend to other parts of the body, usually the upper torso. Patients with rosacea may also present ocular symptoms. It most often affects people of lighter skin, and occurs between the ages of 30 and 50. Although the pathophysiology of rosacea is still unclear, it is probably a multifactorial disease that can be caused or exacerbated by various internal and external factors. It manifests itself in several clinical forms on the basis of which it is divided into four subtypes: erythematotelangiectatic, papulopustular, phymatous and ocular rosacea. Topical use of brimonidine, ivermectin and azelaic acid, as well as oral use of doxycycline and isotretinoin, have the most convincing evidence of the effectiveness of rosacea therapy. Due to the fact that it affects the face, rosacea has a negative impact on the quality of life and self-confidence of patients, so the application of decorative cosmetics is necessary. The role of health professionals is to advise patients on proper skin care with appropriate cosmetic products, adherence to prescribed therapy and avoiding trigger, which can significantly contribute to improving the quality of life and mental state of patients.

• Keywords: rozaceja; farmakoterapija; laserski tretmani
• Keywords (english): rosacea; pharmacotherapy; laser treatments
• Language: croatian
• URN:NBN: urn:nbn:hr:163:418893
• Study programme: Title: Pharmacy; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: magistar/magistra farmacije (magistar/magistra farmacije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2022-03-28 13:41:27