Elementarna onečišćenja u formuliranim dodacima prehrani za liječenje upalnih bolesti crijeva

master's thesis

• Title (english): Elemental impurities in formulated dietary supplements for the treatment of inflammatory bowel diseases
• Author: Marko Ćorković
• Mentor: Daniela Amidžić Klarić (mentor)
• Committee member: Daniela Amidžić Klarić (predsjednik povjerenstva)
• Committee member: Laura Nižić Nodilo (član povjerenstva)
• Committee member: Domagoj Kifer (član povjerenstva)
• Granter: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of pharmaceutical analysis); Zagreb
• Defense date and country: 2024-07-12, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract

U 21. stoljeću primijećen je porast oboljelih od upalnih bolesti crijeva zbog industrijalizacije i
modernog načina života. Liječenje se fokusira na indukciju i održavanje remisije pomoću lijekova
iz različitih farmakoterapijskih skupina. Nerijetko se, zbog neučinkovitosti ili sigurnosnog profila
terapije, pacijenti okreću dodacima prehrani o kojima se provodi i sve veći broj znanstvenih
istraživanja. Budući da se primjenjuju dugotrajno, iznimno je važna kvaliteta proizvoda. Kurkuma,
indijski tamjanovac i justicija biljke su čiji se ekstrakti nalaze u brojnim dodacima prehrani za
liječenje upalnih bolesti crijeva na tržištu. Stoga je cilj ovog rada bio odrediti sadržaj kroma, nikla i
selena, elementarnih onečišćenja i potencijalno toksičnih tvari, u analiziranim dodacima prehrani.
Sadržaj navedenih kemijskih elemenata određen je metodom grafitne atomske apsorpcijske
spektrometrije. Dobiveni rezultati upućuju na povezanost sadržaja elementarnih onečišćenja i vrste
kapsule. Količine elementarnih onečišćenja u analiziranim dodacima prehrani zadovoljavaju
zahtjeve važećih ICH Q3D smjernica o najvećem dozvoljenom dnevnom unosu elementarnog
onečišćenja farmaceutskim proizvodom.

Abstract (english)

In the 21st century, there has been an observed increase in cases of inflammatory bowel disease due
to industrialization and modern lifestyles. Treatment focuses on inducing and maintaining remission
through medications from various pharmacotherapeutic groups. Due to the inefficacy or safety
profile of the therapy, patients often turn to dietary supplements, which are also the subject of
increasing scientific research. Since these supplements are used long-term, the quality of the
products is extremely important. Turmeric, Indian frankincense, and King of Bitters are plants whose
extracts are found in numerous dietary supplements for the treatment of inflammatory bowel
diseases on the market. Therefore, the aim of this study was to determine the content of chromium,
nickel, and selenium as elemental impurities and potentially toxic substances in the analyzed dietary
supplements. The content of these chemical elements was determined using the graphite furnace
atomic absorption spectrometry method. The obtained results showed a correlation between the
content of elemental impurities and the type of capsule. The amounts of elemental impurities in the
analyzed dietary supplements meet the requirements of the current ICH Q3D guidelines on the
maximum daily intake of elemental impurities by a pharmaceutical product.

• Keywords: elementarna onečišćenja; grafitna tehnika; dodaci prehrani; upalne bolesti crijeva; krom; nikal; selen
• Keywords (english): elemental impurities; graphite furnace; dietary supplements; inflammatory bowel disease; chromium; nickel; selenium
• Language: croatian
• URN:NBN: urn:nbn:hr:163:979904
• Study programme: Title: Pharmacy - integrated undergraduate and graduate - university study; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: sveučilišni magistar farmacije (sveučilišni magistar farmacije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Embargoed access; Embargo expiration date: 2026-07-12
• Created on: 2024-09-25 13:32:29