Fizikalno-kemijska karakterizacija dodataka prehrani koji sadrže fitoestrogene

master's thesis

• Title (english): Mechanical property analysis of dietary supplements containing phytoestrogens
• Author: Lucija Topolovec
• Mentor: Ana Mornar Turk (mentor)
• Committee member: Ana Mornar Turk (predsjednik povjerenstva)
• Committee member: Daniela Amidžić Klarić (član povjerenstva)
• Committee member: Snježana Zubčić (član povjerenstva)
• Granter: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of pharmaceutical analysis); Zagreb
• Defense date and country: 2024-07-25, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract

Uporaba dodataka prehrani sve je zastupljenija kao dio zdravog života, zbog čega se javlja sve veći
broj dostupnih pripravaka na tržištu. Važno je imati na umu da se kvaliteta različitih dodataka
prehrani može bitno razlikovati, što znači da njihova učinkovitost neće biti jednaka. Kako bi se
osigurala učinkovitost, ali i sigurnost primjene dodataka prehrani potrebno je poznavati o kojim
svojstvima ovisi njihova kvaliteta te redovito provoditi ispitivanja tih svojstava. Mehanička svojstva
gotovih pripravaka i sirovina korištenih u njihovoj proizvodnji vrlo su bitna svojstva o kojima ovisi
funkcionalnost pripravaka.
Cilj ovog ispitivanja bio je ispitati mehanička svojstva skupine dodataka prehrani i sirovina koje
sadrže fitoestrogene. Ispitani su gotovi pripravci u obliku tableta i kapsula, kojima su određene
varijabilnost masa, rastrošljivost te raspadljivost, kao i prašci koji se koriste kao sirovine u
proizvodnji dodataka prehrani, kojima je ispitana nasipna gustoća i gustoća nakon potresanja te su
izračunati Hausnerov omjer i indeks kompresibilnosti.
U ispitivanju varijabilnosti mase sve ispitane kapsule imale su odstupanje od prosječne mase uzorka
unutar dozvoljenih granica od 10 %. Ispitane tablete također su imale odstupanje od prosječne mase
unutar dozvoljenih granica od 5 %. U ispitivanju rastrošljivosti kod ispitivanih tableta zabilježeno
je smanjenje mase tableta koje je bilo unutar dozvoljenih granica od 1 %. U ispitivanju raspadljivosti
svi uzorci u obliku kapsula raspali su se unutar propisanog vremena od 30 minuta. Kod uzorka u
obliku tableta 5 ispitanih tableta nije se u potpunosti raspalo unutar propisanog vremenskog
intervala. Jedan od ispitanih prašaka imao je svojstva tečenja klasificirana kao prolazna, dok su
preostala dva praška imala svojstva tečenja klasificirana kao vrlo loša.

Abstract (english)

The use of dietary supplements is more and more prevalent as a part of a healthy lifestyle, which
causes and increase of the number of products available on the market. It’s important to keep in
mind that that the quality of different dietary supplements can vary greatly, which means their
efficacy won’t be equal. To ensure efficacy, but also safety of dietary supplement use it’s necessary
to know which properties affect their quality and regularly perform tests of those properties.
Mechanical properties of end products and raw materials used in their manufacture are very
important properties that affect performance of dietary supplements.
The aim of this study was to test the mechanical properties of a group of dietary supplements and
raw materials containing phytoestrogens. End products in the form of tablets and capsules were
tested, determining their mass variability, friability, and disintegration, as well as powders that can
be used in manufacture of dietary supplements, which had their bulk density and tapped density
tested, based on which their Hausner ratio and compressibility index were calculated.
In mass variability testing all tested capsules deviated from the corresponding average mass within
the allowed limit of 10%. The tested tablets also deviated from the average mass within the allowed
limit of 5%. In friability testing the tested tablets showed the loss of mass within the allowed limit
of 1%. In disintegration testing all samples in the form of hard capsules disintegrated within the
prescribed time frame of 30 minutes. For the sample in the form of tablets, 5 tested tablets failed to
fully disintegrate within the prescribed time frame of 30 minutes. One of the tested powder samples
had passable flow properties, while the other two samples very poor flow properties.

• Keywords: dodaci prehrani; fitoestrogeni
• Keywords (english): dietary supplements; phytoestrogens; U. S. Pharmacopoeia
• Language: croatian
• URN:NBN: urn:nbn:hr:163:519772
• Study programme: Title: Pharmacy - integrated undergraduate and graduate - university study; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: sveučilišni magistar farmacije (sveučilišni magistar farmacije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2024-10-10 11:51:24