Učinci hrane i pića na oralno primijenjene lijekove prilagođenog oslobađanja djelatne tvari

master's thesis

• Title (english): The effects of food and beverages on orally applied modified-release dosage forms
• Author: Ana Radošević
• Mentor: Ivan Pepić (mentor)
• Committee member: Ivan Pepić
• Committee member: Jasmina Lovrić
• Committee member: Lovorka Vujić
• Granter: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of pharmaceutical technology); Zagreb
• Defense date and country: 2015-07-01, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract

Fiziologija probavnog sustava složena je i ovisna o brojnim čimbenicima (patofiziološko stanje probavnog sustava, prisutnost i sastav hrane i pića u probavnom sustavu), a koji značajno mogu utjecati na bioraspoloživost lijekova primjenjenih oralnim putem. U ovom diplomskom radu prikazani su i objašnjenji brojni primjeri utjecaja hrane i pića na djelotvornost i sigurnost primjene lijekova izrađenih u farmaceutskom obliku pripravaka prilagođenog oslobađanja djelatne tvari. Glavni je cilj primjene takvih lijekova osigurati produljeni terapijski učinak i smanjiti nuspojave uslijed fluktuacija koncentracije djelatne tvari u sistemskoj cirkulaciji. Hrana i piće na različite načine utječu na oslobađanje djelatne tvari iz farmaceutskog oblika, a na taj način neizravno utječu i na brzinu i obim apsorpcije djelatne tvari iz probavnog sustava. Istodobna primjena hrane i pića uz takve farmaceutske oblike u određenim slučajevima rezultira narušavanjem mehanizma prilagođenog oslobađanja djelatne tvari, odnosno promjenama djelotvornosti i sigurnosnog profila lijeka. Budućim inovativnim rješenjima u području tehnologije izrade farmaceutskih oblika prilagođenog oslobađanja djelatne tvari očekuje se da će biti moguće u zadovoljavajućem obimu prevladati međudjelovanja lijeka u probavnom sustavu nakon oralne primjene uz hranu i piće.

Abstract (english)

Gastrointestinal physiology is complex and dependent upon many factors (pathophysiologic condition of gastrointestinal tract, presence and composition of food and beverages in gastrointestinal tract), which can remarkably affect bioavalability of orally administred drugs. Numerous examples of the impact of food and beverages on efficacy and safety of administration of drugs made in pharmaceutical form of preparation with modifed release of active ingredient are presented and elucidated in this thesis paper. The main goal when administrating these dosage forms is to ensure sustained therapeutic effect and to decrease side effects due to fluctuations in systemic concentration. Food and beverages affect release of active ingredient from dosage form in many distinctive ways, indirecty affecting speed and extent of its absorption. In certain cases simultaneous intake of food and beverages with these dosage forms can result with disturbance of mechanism of modified release of active ingredient, and respectively with changes in efficacy and drug safety profile. It is expected that it will be possible to overcome interactions of drugs with food and beverages after oral administration with future inovative solutions in field of technology of preparation of modified release dosage forms.

• Keywords: bioraspoloživost lijeka; prilagođeno oslobađanje djelatne tvari; produljeni učinak lijeka
• Keywords (english): bioavalability of drug; modified release of active ingredient; sustained therapeutic effect
• Language: croatian
• URN:NBN: urn:nbn:hr:163:793054
• Study programme: Title: Pharmacy; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: magistar/magistra farmacije (magistar/magistra farmacije)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2016-01-18 13:12:05