A convenient synthesis of new NSAID esters containing amino acid, urea and amide moieties

Scientific paper - Preliminary note / Short communication

• Author: Ivana Perković
• Author: Zrinka Rajić Džolić
• Author: Branka Zorc
• Author's institution: University of Zagreb; Faculty of Pharmacy and Biochemistry; (Department of medicinal chemistry)
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Pharmacy; Pharmacy

Abstract (english)

A convenient synthetic method for the preparation of novel NSAID twin esters 6a-i containing amino acid residue, urea and amide moieties has been developed. The synthetic pathway applied for the preparation of target compounds and key intermediates 1-benzotriazolecarboxylic acid chloride (1), NSAID benzotriazolides 2a-c and N-(1-benzotriazolecarbonyl)-amino acids 3a-d involved benzotriazole as a synthetic auxiliary. The final preparation step of esters 6a-i included the solvent-free reaction of compounds 2a-c with amino acid derivatives 5a-g, bearing two hydroxyl groups, one at each terminal, beside urea and amide functionalities.

• Keywords (english): NSAID; ester; amino acid; benzotriazole; urea; amide
• Language: english
• Publication type: Scientific paper - Preliminary note / Short communication
• Publication status: Published
• Peer review: Peer review
• Publication version: Published version
• Journal title: Acta Pharmaceutica
• Numbering: vol. 63, no. 3, pp. 409-418
• p-ISSN: 1330-0075
• e-ISSN: 1846-9558
• DOI: https://doi.org/10.2478/acph-2013-0023
• URN:NBN: urn:nbn:hr:163:609022
• Publication: 2013-09-30
• Document URL: http://hrcak.srce.hr/102049
• Type of resource: Text
• Access conditions: Open access
• Created on: 2017-06-14 15:03:21