Znanstveni rad - Prethodno/kratko priopćenje
A convenient synthesis of new NSAID esters containing amino acid, urea and amide moieties

Perković, Ivana; Rajić Džolić, Zrinka; Zorc, Branka (2013)
Podaci o radu
Jezik rada engleski
Naslov (engleski)A convenient synthesis of new NSAID esters containing amino acid, urea and amide moieties
AutorPerković, Ivana
Rajić Džolić, Zrinka
Zorc, Branka
Sažetak rada (engleski)
A convenient synthetic method for the preparation of novel NSAID twin esters 6a-i containing amino acid residue, urea and amide moieties has been developed. The synthetic pathway applied for the preparation of target compounds and key intermediates 1-benzotriazolecarboxylic acid chloride (1), NSAID benzotriazolides 2a-c and N-(1-benzotriazolecarbonyl)-amino acids 3a-d involved benzotriazole as a synthetic auxiliary. The final preparation step of esters 6a-i included the solvent-free reaction of compounds 2a-c with amino acid derivatives 5a-g, bearing two hydroxyl groups, one at each terminal, beside urea and amide functionalities.
Ključne riječi (engleski)NSAID ester amino acid benzotriazole urea amide
Vrsta radaznanstveni rad - prethodno/kratko priopćenje
Status objave radaobjavljen
Vrsta recenzijerecenziran
Naslov časopisaActa Pharmaceutica
Brojčani podaci2013, Vol. 63, br. 3, str. 409-418
ISSN1330-0075
e-ISSN1846-9558
Datumdatum objave publikacije: 30.09.2013.
Oznaka DOI10.2478/acph-2013-0023
URL radahttp://hrcak.srce.hr/102049
Znanstveno područjeBIOMEDICINA I ZDRAVSTVO
Farmacija
Farmacija
UstanovaSveučilište u Zagrebu, Farmaceutsko-biokemijski fakultet
URN:NBNhttps://urn.nsk.hr/urn:nbn:hr:163:609022