prikaz prve stranice dokumenta Evaluation of stability and in vitro wound healing potential of melatonin loaded (lipid enriched) chitosan based microspheres
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Scientific paper - Original scientific paper
Evaluation of stability and in vitro wound healing potential of melatonin loaded (lipid enriched) chitosan based microspheres
Acta Pharmaceutica, 69 (2019), 4; 635-648. https://doi.org/10.2478/acph-2019-0049
Duvnjak Romić, Marieta; Sušac, Anja; Lovrić, Jasmina; Cetina-Čižmek, Biserka; Filipović-Grčić, Jelena; Hafner, Anita

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Duvnjak Romić, M., Sušac, A., Lovrić, J., Cetina Čižmek, B., Filipović Grčić, J. & Hafner, A. (2019). Evaluation of stability and in vitro wound healing potential of melatonin loaded (lipid enriched) chitosan based microspheres. Acta Pharmaceutica, 69. (4), 635-648. doi: 10.2478/acph-2019-0049

Duvnjak Romić, Marieta, et al. "Evaluation of stability and in vitro wound healing potential of melatonin loaded (lipid enriched) chitosan based microspheres." Acta Pharmaceutica, vol. 69, no. 4, 2019, pp. 635-648. https://doi.org/10.2478/acph-2019-0049

Duvnjak Romić, Marieta, Anja Sušac, Jasmina Lovrić, Biserka Cetina Čižmek, Jelena Filipović Grčić and Anita Hafner. "Evaluation of stability and in vitro wound healing potential of melatonin loaded (lipid enriched) chitosan based microspheres." Acta Pharmaceutica 69, no. 4 (2019): 635-648. https://doi.org/10.2478/acph-2019-0049

Duvnjak Romić, M., et al. (2019) 'Evaluation of stability and in vitro wound healing potential of melatonin loaded (lipid enriched) chitosan based microspheres', Acta Pharmaceutica, 69(4), pp. 635-648. doi: 10.2478/acph-2019-0049

Duvnjak Romić M, Sušac A, Lovrić J, Cetina Čižmek B, Filipović Grčić J, Hafner A. Evaluation of stability and in vitro wound healing potential of melatonin loaded (lipid enriched) chitosan based microspheres. Acta Pharmaceutica [Internet]. 2019 [cited 2025 January 03];69(4):635-648. doi: 10.2478/acph-2019-0049

M. Duvnjak Romić, A. Sušac, J. Lovrić, B. Cetina Čižmek, J. Filipović Grčić and A. Hafner, "Evaluation of stability and in vitro wound healing potential of melatonin loaded (lipid enriched) chitosan based microspheres", Acta Pharmaceutica, vol. 69, no. 4, pp. 635-648, 2019. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:163:578073. [Accessed: 03 January 2025]

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Title (english)Evaluation of stability and in vitro wound healing potential of melatonin loaded (lipid enriched) chitosan based microspheres
AuthorMarieta Duvnjak Romić
AuthorAnja Sušac
AuthorJasmina Lovrić
AuthorBiserka Cetina-Čižmek
AuthorJelena Filipović-Grčić
AuthorAnita Hafner
Author's institutionUniversity of Zagreb
Faculty of Pharmacy and Biochemistry
(Department of pharmaceutical technology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Pharmacy
Pharmacy
Abstract (english)
The aim of this study was to evaluate long-term stability and assess the wound healing potential of the innovative melatonin-loaded lipid-enriched hybrid system compared to conventional melatonin-loaded chitosan microspheres. The hybrid system contained nanostructured lipid carrier incorporated in the chitosan matrix, in order to modify melatonin release and alter physicochemical characteristics of the delivery system. Stability testing was performed during a six-month period under two conditions - refrigerated (5±3 °C) and at room temperature (25 ± 2 °C/60 ± 5 % RH). Samples stored at both conditions were analyzed in terms of particle size, zeta potential, moisture content and thermal properties. At the end of testing, drug content was determined in all samples. Dressings wound healing potential was assessed by in vitro scratch test using human skin fibroblast cell line. Although both systems showed good stability characteristics, the addition of lipids in the system has improved its wound healing potential.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleActa Pharmaceutica
Numberingvol. 69, no. 4, pp. 635-648
p-ISSN1330-0075
e-ISSN1846-9558
DOIhttps://doi.org/10.2478/acph-2019-0049
URN:NBNurn:nbn:hr:163:578073
Publication2019
Document URLhttps://hrcak.srce.hr/225427
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2020-04-07 15:00:13